SCOPe 2.01: Domain d1thp.1: 1thp A:,B:

Lineage for d1thp.1 (1thp A:,B:)

1. Root: SCOPe 2.01

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (48 proteins)

6. Protein Thrombin [50531] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50532] (160 PDB entries)
   Uniprot P00734 331-361,364-421 ! Uniprot P00734 334-360 364-510 518-619 ! Uniprot P00734 328-620 ! Uniprot P00734 355-621 ! Uniprot P00734 328-620

8. Domain d1thp.1: 1thp A:,B: [26140]
   complexed with 0g6; mutant

Details for d1thp.1

PDB Entry: 1thp, 2.1 Å

PDB Description: structure of human alpha-thrombin y225p mutant bound to d-phe-pro-arg- chloromethylketone

PDB Compounds: (A:) protein (thrombin light chain), (B:) protein (thrombin heavy chain)

SCOPe Domain Sequences for d1thp.1:

Sequence, based on SEQRES records:

>g1thp.1 b.47.1.2 (A:,B:) Thrombin {Human (Homo sapiens) [TaxId: 9606]}
adcglrplfekksledkterellesyiXivegsdaeigmspwqvmlfrkspqellcgasl
isdrwvltaahcllyppwdknftendllvrigkhsrtryerniekismlekiyihprynw
renldrdialmklkkpvafsdyihpvclpdretaasllqagykgrvtgwgnlketwtanv
gkgqpsvlqvvnlpiverpvckdstriritdnmfcagykpdegkrgdacegdsggpfvmk
spfnnrwyqmgivswgegcdrdgkpgfythvfrlkkwiqkvidqf

Sequence, based on observed residues (ATOM records):

>g1thp.1 b.47.1.2 (A:,B:) Thrombin {Human (Homo sapiens) [TaxId: 9606]}
adcglrplfekksledkterellesyiXivegsdaeigmspwqvmlfrkspqellcgasl
isdrwvltaahcllyppwdknftendllvrigkhsrtryerniekismlekiyihprynw
renldrdialmklkkpvafsdyihpvclpdretaasllqagykgrvtgwgnlkegqpsvl
qvvnlpiverpvckdstriritdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwy
qmgivswgegcdrdgkpgfythvfrlkkwiqkvidqf

Timeline for d1thp.1:

• d1thp.1 first appeared (with stable ids) in SCOP 1.55
  
• d1thp.1 appears in SCOP 1.75
  
• d1thp.1 appears in SCOPe 2.02
  
• d1thp.1 appears in the current release, SCOPe 2.08