SCOPe 2.01: Family b.47.1.2: Eukaryotic proteases

Lineage for Family b.47.1.2: Eukaryotic proteases

1. Root: SCOPe 2.01

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (48 proteins)

Proteins:

1. (alpha,gamma)-chymotrypsin(ogen) [50522] (3 species)

   1. Species Cow (Bos taurus) [TaxId:9913] [50523] (57 PDB entries)
      Uniprot P00766

   2. Species Norway rat (Rattus norvegicus) [TaxId:10116] [89340] (1 PDB entry)

   3. Species Red fire ant (Solenopsis invicta) [TaxId:13686] [50524] (1 PDB entry)

2. 7S NGF protease subunits [50559] (1 species)
   two pairs of homologous but non-identical chains

   • Species Mouse (Mus musculus) [TaxId:10090] [50560] (1 PDB entry)

3. Activated protein c (autoprothrombin IIa) [50579] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [50580] (2 PDB entries)

4. Alpha tryptase I [89341] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [89342] (1 PDB entry)

5. Beta-acrosin [50593] (2 species)

   1. Species Pig (Sus scrofa) [TaxId:9823] [50595] (1 PDB entry)

   2. Species Sheep (Ovis aries) [TaxId:9940] [50594] (1 PDB entry)

6. beta-Tryptase [50546] (1 species)
   ring-like tetramer with active sites facing a central pore

   • Species Human (Homo sapiens) [TaxId:9606] [50547] (12 PDB entries)

7. Cathepsin G [50548] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [50549] (3 PDB entries)

8. Chymase (mast cell protease I) [89343] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [89344] (7 PDB entries)

9. Chymase II (mast cell proteinase II) [50552] (1 species)

   • Species Rat (Rattus rattus) [TaxId:10117] [50553] (1 PDB entry)

10. Coagulation factor IXa, protease domain [50583] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [50585] (5 PDB entries)

    2. Species Pig (Sus scrofa) [TaxId:9823] [50584] (2 PDB entries)

11. Coagulation factor VIIa [50550] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [50551] (28 PDB entries)
      Uniprot P08709 213-466 ! Uniprot P08709 213-446

12. Coagulation factor Xa, protease domain [50574] (2 species)

    1. Species Cow (Bos taurus) [TaxId:9913] [50576] (1 PDB entry)

    2. Species Human (Homo sapiens) [TaxId:9606] [50575] (43 PDB entries)
       Uniprot P00742 235-467

13. Coagulation factor Xa-trypsin chimera [50577] (1 species)

    • Species Synthetic, based on Homo sapiens sequence [50578] (1 PDB entry)
      Xa: residues 16-121; trypsin: residues 122-246

14. Coagulation factor XI [117237] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [117238] (24 PDB entries)
      Uniprot P03951 388-624

15. Complement C1R protease, catalytic domain [74976] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [74977] (4 PDB entries)

16. Complement C1S protease, catalytic domain [63789] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [63790] (1 PDB entry)

17. Crab collagenase [50527] (1 species)

    • Species Atlantic sand fiddler crab (Uca pugilator) [TaxId:6772] [50528] (1 PDB entry)

18. Duodenase [63791] (1 species)
    new serine protease

    • Species Cow (Bos taurus) [TaxId:9913] [63792] (1 PDB entry)

19. Elastase [50536] (4 species)

    1. Species Atlantic salmon (Salmo salar) [TaxId:8030] [50539] (1 PDB entry)

    2. Species Human (Homo sapiens) [TaxId:9606] [50537] (5 PDB entries)

    3. Species Pig (Sus scrofa) [TaxId:9823] [50538] (114 PDB entries)

    4. Species Worm (Eisenia fetida) [TaxId:6396] [74973] (1 PDB entry)
       fibrinolytic enzyme component A

20. Enteropeptidase (enterokinase light chain) [50540] (1 species)

    • Species Cow (Bos taurus) [TaxId:9913] [50541] (1 PDB entry)

21. Factor B [50561] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [50562] (4 PDB entries)
      Uniprot P00751 268-764

22. Factor D [50563] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [50564] (9 PDB entries)

23. Granzyme A [89345] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [89346] (2 PDB entries)

24. Granzyme B [50590] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [50592] (2 PDB entries)

    2. Species Norway rat (Rattus norvegicus) [TaxId:10116] [50591] (1 PDB entry)

25. Granzyme K [82124] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [82125] (2 PDB entries)

26. Heparin binding protein, HBP [50544] (1 species)
    multifunctional protein (synonym: CAP37, azurocidin)

    • Species Human (Homo sapiens) [TaxId:9606] [50545] (4 PDB entries)

27. Hepatocyte growth factor, HGF [110239] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [110240] (2 PDB entries)
      Uniprot P14210 495-728 ! Uniprot P14210 495-722

28. Hepsin, catalytic domain [101813] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [101814] (4 PDB entries)
      Uniprot P05981 163-417

29. HL collagenase [50529] (1 species)

    • Species Common cattle grub (Hypoderma lineatum) [TaxId:7389] [50530] (2 PDB entries)

30. Kallikrein 6 [74974] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [74975] (3 PDB entries)

31. Kallikrein A [50555] (1 species)

    • Species Pig (Sus scrofa) [TaxId:9823] [50556] (3 PDB entries)

32. Kallikrein-13 [50572] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [50573] (1 PDB entry)

33. Mannan-binding lectin serine protease 2 (MASP-2), catalytic domain [110241] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [110242] (2 PDB entries)
      Uniprot O00187 366-686

34. Matriptase MTSP1 [69284] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [69285] (7 PDB entries)

35. Myeloblastin, PR3 [50581] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [50582] (1 PDB entry)

36. Neuropsin [50525] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [50526] (1 PDB entry)

37. Plasmin(ogen), catalytic domain [50588] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [50589] (7 PDB entries)

38. Procarboxypeptidase A-S6 subunit III (zymogen E) [50534] (1 species)

    • Species Cow (Bos taurus) [TaxId:9913] [50535] (2 PDB entries)

39. Prostate specific antigen (PSA kallikrein) [82122] (1 species)

    • Species Horse (Equus caballus) [TaxId:9796] [82123] (1 PDB entry)

40. Single chain tissue plasminogen activator [50567] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [50568] (1 PDB entry)

    2. Species Vampire bat (Desmodus rotundus) [TaxId:9430] [50569] (1 PDB entry)

41. Thrombin [50531] (2 species)

    1. Species Cow (Bos taurus) [TaxId:9913] [50533] (26 PDB entries)
       Uniprot P00734 333-622

    2. Species Human (Homo sapiens) [TaxId:9606] [50532] (160 PDB entries)
       Uniprot P00734 331-361,364-421 ! Uniprot P00734 334-360 364-510 518-619 ! Uniprot P00734 328-620 ! Uniprot P00734 355-621 ! Uniprot P00734 328-620

42. Tonin [50557] (1 species)

    • Species Rat (Rattus rattus) [TaxId:10117] [50558] (1 PDB entry)

43. Trypsin(ogen) [50515] (9 species)

    1. Species Atlantic salmon (Salmo salar) [TaxId:8030] [50520] (11 PDB entries)

    2. Species Chum salmon (Oncorhynchus keta) [TaxId:8018] [82121] (1 PDB entry)

    3. Species Cow (Bos taurus) [TaxId:9913] [50516] (340 PDB entries)
       Uniprot P00760

    4. Species Fungus (Fusarium oxysporum) [TaxId:5507] [50521] (16 PDB entries)

    5. Species Human (Homo sapiens) [TaxId:9606] [50519] (2 PDB entries)

    6. Species Human (Homo sapiens), trypsin IV (brain isoform) [TaxId:9606] [69283] (6 PDB entries)

    7. Species Narrow-clawed crayfish (Pontastacus leptodactylus) [TaxId:6717] [141385] (1 PDB entry)
       Uniprot Q52V24 1-237

    8. Species Norway rat (Rattus norvegicus) [TaxId:10116] [50518] (36 PDB entries)

    9. Species Pig (Sus scrofa) [TaxId:9823] [50517] (24 PDB entries)
       Uniprot P00761 9-231 ! Uniprot P00761

44. Two-chain tissue plasminogen activator (TC)-T-PA [50565] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [50566] (2 PDB entries)

45. Urokinase [50542] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [50543] (1 PDB entry)

46. Urokinase-type plasminogen activator (LMW U-PA), catalytic domain [50586] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [50587] (52 PDB entries)
      Uniprot P00749 156-178,179-424

47. Venom serine protease [50570] (2 species)

    1. Species Chinese green tree viper (Trimeresurus stejnegeri) [TaxId:39682] [50571] (1 PDB entry)

    2. Species Hundred-pace snake (Agkistrodon acutus) [TaxId:36307] [110238] (2 PDB entries)
       Uniprot Q9I8X1

48. automated matches [190044] (7 species)
    not a true protein

    1. Species Agkistrodon contortrix [TaxId:8713] [187405] (2 PDB entries)

    2. Species Atlantic cod (Gadus morhua) [TaxId:8049] [188345] (1 PDB entry)

    3. Species Chum salmon (Oncorhynchus keta) [TaxId:8018] [189036] (3 PDB entries)

    4. Species Cow (Bos taurus) [TaxId:9913] [187001] (7 PDB entries)

    5. Species Golden hamster (Mesocricetus auratus) [TaxId:10036] [188254] (1 PDB entry)

    6. Species Human (Homo sapiens) [TaxId:9606] [187233] (110 PDB entries)

    7. Species Mouse (Mus musculus) [TaxId:10090] [188816] (2 PDB entries)

More info for Family b.47.1.2: Eukaryotic proteases

Timeline for Family b.47.1.2: Eukaryotic proteases:

• Family b.47.1.2: Eukaryotic proteases first appeared (with stable ids) in SCOP 1.55
  
• Family b.47.1.2: Eukaryotic proteases appears in SCOP 1.75
  
• Family b.47.1.2: Eukaryotic proteases appears in SCOPe 2.02
  
• Family b.47.1.2: Eukaryotic proteases appears in the current release, SCOPe 2.08