Lineage for Protein: Thrombin

  1. Root: SCOPe 2.01
  2. 929298Class b: All beta proteins [48724] (174 folds)
  3. 952974Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
    barrel, closed; n=6, S=8; greek-key
    duplication: consists of two domains of the same fold
  4. 952975Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families) (S)
  5. 953177Family b.47.1.2: Eukaryotic proteases [50514] (48 proteins)
  6. 953769Protein Thrombin [50531] (2 species)

Species:

  1. 953770Cow (Bos taurus) [TaxId:9913] [50533] (26 PDB entries)
    Uniprot P00734 333-622
    1. Domains for 1a0h:
      1. 953814Domain d1a0h.1: 1a0h A:271-320,B: [26229]
        Other proteins in same PDB: d1a0ha1, d1a0hd1
        complexed with 0g6
      2. 953815Domain d1a0h.2: 1a0h D:271-320,E: [26230]
        Other proteins in same PDB: d1a0ha1, d1a0hd1
        complexed with 0g6
    2. Domain for 1avg:
    3. Domains for 1bbr:
      1. 953789Domain d1bbr.1: 1bbr L:,H:,E: [26207]
      2. 953790Domain d1bbr.2: 1bbr J:,K: [26208]
      3. 953791Domain d1bbr.3: 1bbr M:,N: [26209]
    4. Domains for 1bth:
      1. 953787Domain d1bth.1: 1bth L:,H: [26205]
        Other proteins in same PDB: d1bthp_, d1bthq_
      2. 953788Domain d1bth.2: 1bth J:,K: [26206]
        Other proteins in same PDB: d1bthp_, d1bthq_
    5. Domain for 1etr:
    6. Domain for 1ets:
    7. Domain for 1ett:
    8. Domain for 1hrt:
    9. Domain for 1id5:
    10. Domains for 1mkw:
      1. 953794Domain d1mkw.1: 1mkw L:,H: [26211]
        chain K is pretrombin-2
      2. 953795Domain d1mkwk_: 1mkw K: [26212]
        chain K is pretrombin-2
    11. Domains for 1mkx:
      1. 953782Domain d1mkx.1: 1mkx L:,H: [26203]
        chain K is pretrombin-2
      2. 953783Domain d1mkxk_: 1mkx K: [26204]
        chain K is pretrombin-2
    12. Domain for 1sb1:
    13. Domains for 1sfq:
      1. 953773Domain d1sfq.1: 1sfq A:,B: [105498]
        complexed with 0g6, na, nag; mutant
      2. 953774Domain d1sfq.2: 1sfq D:,E: [105499]
        complexed with 0g6, na, nag; mutant
    14. Domains for 1sg8:
      1. 953792Domain d1sg8.1: 1sg8 A:,B: [105524]
        complexed with na, nag
      2. 953793Domain d1sg8.2: 1sg8 D:,E: [105525]
        complexed with na, nag
    15. Domains for 1sgi:
      1. 953785Domain d1sgi.1: 1sgi A:,B: [105533]
        complexed with nag
      2. 953786Domain d1sgi.2: 1sgi D:,E: [105534]
        complexed with nag
    16. Domains for 1shh:
      1. 953771Domain d1shh.1: 1shh A:,B: [105552]
        complexed with 0g6, nag
      2. 953772Domain d1shh.2: 1shh D:,E: [105553]
        complexed with 0g6, nag
    17. Domain for 1ta2:
    18. Domain for 1ta6:
    19. Domains for 1tbq:
      1. 953804Domain d1tbq.1: 1tbq L:,H: [26219]
        Other proteins in same PDB: d1tbqr1, d1tbqr2, d1tbqs1, d1tbqs2
      2. 953805Domain d1tbq.2: 1tbq J:,K: [26220]
        Other proteins in same PDB: d1tbqr1, d1tbqr2, d1tbqs1, d1tbqs2
    20. Domains for 1tbr:
      1. 953802Domain d1tbr.1: 1tbr L:,H: [26217]
        Other proteins in same PDB: d1tbrr1, d1tbrr2, d1tbrs1, d1tbrs2
      2. 953803Domain d1tbr.2: 1tbr J:,K: [26218]
        Other proteins in same PDB: d1tbrr1, d1tbrr2, d1tbrs1, d1tbrs2
    21. Domains for 1toc:
      1. 953810Domain d1toc.1: 1toc A:,B: [26225]
        Other proteins in same PDB: d1tocr1, d1tocr2, d1tocs1, d1tocs2, d1toct1, d1toct2, d1tocu1, d1tocu2
      2. 953811Domain d1toc.2: 1toc C:,D: [26226]
        Other proteins in same PDB: d1tocr1, d1tocr2, d1tocs1, d1tocs2, d1toct1, d1toct2, d1tocu1, d1tocu2
      3. 953812Domain d1toc.3: 1toc E:,F: [26227]
        Other proteins in same PDB: d1tocr1, d1tocr2, d1tocs1, d1tocs2, d1toct1, d1toct2, d1tocu1, d1tocu2
      4. 953813Domain d1toc.4: 1toc G:,H: [26228]
        Other proteins in same PDB: d1tocr1, d1tocr2, d1tocs1, d1tocs2, d1toct1, d1toct2, d1tocu1, d1tocu2
    22. Domains for 1ucy:
      1. 953778Domain d1ucy.1: 1ucy L:,H:,E: [26199]
      2. 953779Domain d1ucy.2: 1ucy J:,K: [26200]
      3. 953780Domain d1ucy.3: 1ucy M:,N: [26201]
    23. Domain for 1uvt:
    24. Domain for 1uvu:
    25. Domains for 1vit:
      1. 953808Domain d1vit.1: 1vit L:,H: [26223]
        complexed with nag
      2. 953809Domain d1vit.2: 1vit M:,F:,G: [26224]
        complexed with nag
    26. Domains for 1ycp:
      1. 953798Domain d1ycp.1: 1ycp L:,H: [26214]
        mutant
      2. 953799Domain d1ycp.2: 1ycp J:,K:,M: [26215]
        mutant
  2. 953816Human (Homo sapiens) [TaxId:9606] [50532] (160 PDB entries)
    Uniprot P00734 331-361,364-421 ! Uniprot P00734 334-360 364-510 518-619 ! Uniprot P00734 328-620 ! Uniprot P00734 355-621 ! Uniprot P00734 328-620
    1. Domain for 1a2c:
    2. Domain for 1a3b:
    3. Domain for 1a3e:
    4. Domain for 1a46:
    5. Domain for 1a4w:
    6. Domain for 1a5g:
    7. Domain for 1a61:
    8. Domain for 1abi:
    9. Domain for 1abj:
    10. Domain for 1ad8:
    11. Domain for 1ae8:
    12. Domain for 1afe:
    13. Domain for 1aht:
    14. Domain for 1ai8:
    15. Domain for 1aix:
    16. Domain for 1awf:
    17. Domains for 1awh:
      1. 953985Domain d1awh.1: 1awh A:,B: [26191]
        complexed with gr3
      2. 953986Domain d1awh.2: 1awh C:,D: [26192]
        complexed with gr3
    18. Domain for 1ay6:
    19. Domain for 1b5g:
    20. Domain for 1b7x:
    21. Domain for 1ba8:
    22. Domain for 1bb0:
    23. Domain for 1bcu:
    24. Domain for 1bhx:
    25. Domain for 1bmm:
    26. Domain for 1bmn:
    27. Domain for 1c1u:
    28. Domain for 1c1v:
    29. Domain for 1c1w:
    30. Domain for 1c4u:
    31. Domain for 1c4v:
    32. Domain for 1c4y:
    33. Domain for 1c5l:
    34. Domain for 1c5n:
    35. Domain for 1c5o:
    36. Domain for 1ca8:
    37. Domain for 1d3d:
    38. Domain for 1d3p:
    39. Domain for 1d3q:
    40. Domain for 1d3t:
    41. Domain for 1d4p:
    42. Domain for 1d6w:
    43. Domain for 1d9i:
    44. Domains for 1de7:
      1. 953860Domain d1de7.1: 1de7 L:,H: [26095]
        complexed with na
      2. 953861Domain d1de7.2: 1de7 J:,K: [26096]
        complexed with na
    45. Domain for 1dit:
    46. Domain for 1dm4:
    47. Domain for 1doj:
    48. Domain for 1dwb:
    49. Domain for 1dwc:
    50. Domain for 1dwd:
    51. Domain for 1dwe:
    52. Domains for 1dx5:
      1. 953931Domain d1dx5.1: 1dx5 A:,M: [26155]
        Other proteins in same PDB: d1dx5i1, d1dx5i2, d1dx5i3, d1dx5j1, d1dx5j2, d1dx5j3, d1dx5k1, d1dx5k2, d1dx5k3, d1dx5l1, d1dx5l2, d1dx5l3
        complexed with ca, fmt, na, ndg
      2. 953932Domain d1dx5.2: 1dx5 B:,N: [26156]
        Other proteins in same PDB: d1dx5i1, d1dx5i2, d1dx5i3, d1dx5j1, d1dx5j2, d1dx5j3, d1dx5k1, d1dx5k2, d1dx5k3, d1dx5l1, d1dx5l2, d1dx5l3
        complexed with ca, fmt, na, ndg
      3. 953933Domain d1dx5.3: 1dx5 C:,O: [26157]
        Other proteins in same PDB: d1dx5i1, d1dx5i2, d1dx5i3, d1dx5j1, d1dx5j2, d1dx5j3, d1dx5k1, d1dx5k2, d1dx5k3, d1dx5l1, d1dx5l2, d1dx5l3
        complexed with ca, fmt, na, ndg
      4. 953934Domain d1dx5.4: 1dx5 D:,P: [26158]
        Other proteins in same PDB: d1dx5i1, d1dx5i2, d1dx5i3, d1dx5j1, d1dx5j2, d1dx5j3, d1dx5k1, d1dx5k2, d1dx5k3, d1dx5l1, d1dx5l2, d1dx5l3
        complexed with ca, fmt, na, ndg
    53. Domains for 1e0f:
      1. 953980Domain d1e0f.1: 1e0f A:,D: [26184]
        Other proteins in same PDB: d1e0fi_, d1e0fj_, d1e0fk_
      2. 953981Domain d1e0f.2: 1e0f B:,E: [26185]
        Other proteins in same PDB: d1e0fi_, d1e0fj_, d1e0fk_
      3. 953982Domain d1e0f.3: 1e0f C:,F: [26186]
        Other proteins in same PDB: d1e0fi_, d1e0fj_, d1e0fk_
    54. Domain for 1eb1:
    55. Domain for 1eoj:
    56. Domain for 1eol:
    57. Domain for 1fpc:
    58. Domain for 1fph:
    59. Domain for 1g30:
    60. Domain for 1g32:
    61. Domain for 1g37:
    62. Domain for 1ghv:
    63. Domain for 1ghw:
    64. Domain for 1ghx:
    65. Domain for 1ghy:
    66. Domain for 1gj4:
    67. Domain for 1gj5:
    68. Domain for 1h8d:
    69. Domain for 1h8i:
    70. Domain for 1hag:
    71. Domain for 1hah:
    72. Domain for 1hai:
    73. Domain for 1hao:
    74. Domain for 1hap:
    75. Domain for 1hbt:
    76. Domain for 1hdt:
    77. Domain for 1hgt:
    78. Domains for 1hlt:
      1. 953975Domain d1hlt.1: 1hlt L:,H: [26181]
        complexed with 0g6
      2. 953976Domain d1hlt.2: 1hlt J:,K: [26182]
        complexed with 0g6
    79. Domain for 1hut:
    80. Domain for 1hxe:
    81. Domain for 1hxf:
    82. Domain for 1ihs:
    83. Domain for 1iht:
    84. Domain for 1jmo:
      • 953995Domain d1jmo.1: 1jmo L:,H: [77137]
        Other proteins in same PDB: d1jmoa_
        complex with a heparin cofactor II mutant
        complexed with mpd, na, nag, ndg
    85. Domains for 1jou:
      1. 953849Domain d1jou.1: 1jou A:,B: [63218]
        complexed with acy, gol, na, ndg
      2. 953850Domain d1jou.2: 1jou C:,D: [63219]
        complexed with acy, gol, na, ndg
      3. 953851Domain d1jou.3: 1jou E:,F: [63220]
        complexed with acy, gol, na, ndg
    86. Domain for 1jwt:
    87. Domain for 1k21:
    88. Domain for 1k22:
    89. Domain for 1kts:
    90. Domain for 1ktt:
    91. Domain for 1lhc:
    92. Domain for 1lhd:
    93. Domain for 1lhe:
    94. Domain for 1lhf:
    95. Domain for 1lhg:
    96. Domains for 1mh0:
      1. 953971Domain d1mh0a_: 1mh0 A: [79110]
        anticoagulant slow form
        complexed with nag
      2. 953972Domain d1mh0b_: 1mh0 B: [79111]
        anticoagulant slow form
        complexed with nag
    97. Domain for 1mu6:
    98. Domain for 1mu8:
    99. Domain for 1mue:
    100. Domain for 1nm6:
    101. Domain for 1no9:
    102. Domain for 1nrn:
    103. Domain for 1nro:
    104. Domain for 1nrp:
    105. Domain for 1nrq:
    106. Domain for 1nrr:
    107. Domain for 1nrs:
    108. Domain for 1nt1:
    109. Domains for 1nu7:
      1. 953922Domain d1nu7.1: 1nu7 A:,B: [92189]
        Other proteins in same PDB: d1nu7d1, d1nu7d2, d1nu7h1, d1nu7h2
        complexed with 0zj, hg, imd
      2. 953923Domain d1nu7.2: 1nu7 E:,F: [92190]
        Other proteins in same PDB: d1nu7d1, d1nu7d2, d1nu7h1, d1nu7h2
        complexed with 0zj, hg, imd
    110. Domains for 1nu9:
      1. 953905Domain d1nu9a_: 1nu9 A: [92199]
        Other proteins in same PDB: d1nu9c1, d1nu9c2, d1nu9f1, d1nu9f2
        complexed with 0zj, hg, imd
      2. 953906Domain d1nu9d_: 1nu9 D: [92202]
        Other proteins in same PDB: d1nu9c1, d1nu9c2, d1nu9f1, d1nu9f2
        complexed with 0zj, hg, imd
    111. Domain for 1ny2:
    112. Domain for 1nzq:
    113. Domain for 1o0d:
    114. Domain for 1o2g:
    115. Domain for 1o5g:
    116. Domain for 1ook:
    117. Domain for 1oyt:
    118. Domain for 1p8v:
    119. Domain for 1ppb:
    120. Domain for 1qbv:
    121. Domain for 1qhr:
    122. Domain for 1qj1:
    123. Domain for 1qj6:
    124. Domain for 1qj7:
    125. Domain for 1qur:
    126. Domains for 1rd3:
      1. 953961Domain d1rd3.1: 1rd3 A:,B: [97302]
        complexed with gol, po4
      2. 953962Domain d1rd3.2: 1rd3 C:,D: [97303]
        complexed with gol, po4
    127. Domain for 1riw:
    128. Domain for 1sl3:
    129. Domain for 1sr5:
    130. Domain for 1tb6:
    131. Domain for 1tbz:
    132. Domain for 1thp:
    133. Domain for 1thr:
    134. Domain for 1ths:
    135. Domain for 1tmb:
    136. Domain for 1tmt:
    137. Domain for 1tmu:
    138. Domain for 1tom:
    139. Domains for 1tq0:
      1. 953973Domain d1tq0.1: 1tq0 A:,B: [107196]
        mutant
      2. 953974Domain d1tq0.2: 1tq0 C:,D: [107197]
        mutant
    140. Domain for 1tq7:
    141. Domain for 1uma:
    142. Domain for 1uvs:
    143. Domain for 1vr1:
    144. Domain for 1xm1:
    145. Domains for 1xmn:
      1. 953841Domain d1xmn.1: 1xmn A:,B: [115495]
        complexed with 0g6, gol, na
      2. 953842Domain d1xmn.2: 1xmn C:,D: [115496]
        complexed with 0g6, gol, na
      3. 953843Domain d1xmn.3: 1xmn E:,F: [115497]
        complexed with 0g6, gol, na
      4. 953844Domain d1xmn.4: 1xmn G:,H: [115498]
        complexed with 0g6, gol, na
    146. Domains for 2a45:
      1. 953992Domain d2a45.1: 2a45 A:,B: [162661]
        Other proteins in same PDB: d2a45g_, d2a45h_, d2a45i_, d2a45j_, d2a45k_, d2a45l_
        complexed with 0g6, po4
      2. 953993Domain d2a45.2: 2a45 D:,E: [162662]
        Other proteins in same PDB: d2a45g_, d2a45h_, d2a45i_, d2a45j_, d2a45k_, d2a45l_
        complexed with 0g6, po4
    147. Domain for 2hgt:
    148. Domain for 2hnt:
    149. Domain for 2hpp:
    150. Domain for 2hpq:
    151. Domain for 2thf:
    152. Domain for 3hat:
    153. Domain for 3htc:
    154. Domain for 3k65:
    155. Domain for 3sqe:
    156. Domain for 4htc:
    157. Domain for 4thn:
    158. Domain for 5gds:
    159. Domain for 7kme:
    160. Domain for 8kme:

More info for Protein Thrombin from b.47.1.2: Eukaryotic proteases

Timeline for Protein Thrombin from b.47.1.2: Eukaryotic proteases: