SCOPe 2.06: Domain d4nw7a1: 4nw7 A:324-680

Lineage for d4nw7a1 (4nw7 A:324-680)

1. Root: SCOPe 2.06

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.211: HD-domain/PDEase-like [109603] (1 superfamily)
   multihelical; consists of two different alpha-helical bundles

4. Superfamily a.211.1: HD-domain/PDEase-like [109604] (6 families)

5. Family a.211.1.2: PDEase [48548] (7 proteins)
   Pfam PF00233; multihelical; can be divided into three subdomains

6. Protein automated matches [190370] (1 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187208] (27 PDB entries)

8. Domain d4nw7a1: 4nw7 A:324-680 [260343]
   Other proteins in same PDB: d4nw7a2
   automated match to d3hmva_
   complexed with 2o5, edo, mg, na, zn

Details for d4nw7a1

PDB Entry: 4nw7, 2.15 Å

PDB Description: PDE4 catalytic domain

PDB Compounds: (A:) cAMP-specific 3',5'-cyclic phosphodiesterase 4B

SCOPe Domain Sequences for d4nw7a1:

Sequence, based on SEQRES records:

>d4nw7a1 a.211.1.2 (A:324-680) automated matches {Human (Homo sapiens) [TaxId: 9606]}
sisrfgvntenedhlakeledlnkwglnifnvagyshnrpltcimyaifqerdllktfri
ssdtfitymmtledhyhsdvayhnslhaadvaqsthvllstpaldavftdleilaaifaa
aihdvdhpgvsnqflintnselalmyndesvlenhhlavgfkllqeehcdifmnltkkqr
qtlrkmvidmvlatdmskhmslladlktmvetkkvtssgvllldnytdriqvlrnmvhca
dlsnptkslelyrqwtdrimeeffqqgdkerergmeispmcdkhtasveksqvgfidyiv
hplwetwadlvqpdaqdildtlednrnwyqsmipqspsppldeqnrdcqglmekfqf

Sequence, based on observed residues (ATOM records):

>d4nw7a1 a.211.1.2 (A:324-680) automated matches {Human (Homo sapiens) [TaxId: 9606]}
sisrfgvntenedhlakeledlnkwglnifnvagyshnrpltcimyaifqerdllktfri
ssdtfitymmtledhyhsdvayhnslhaadvaqsthvllstpaldavftdleilaaifaa
aihdvdhpgvsnqflintnselalmyndesvlenhhlavgfkllqeehcdifmnltkkqr
qtlrkmvidmvlatdmskhmslladlktmvetkkvtssgvllldnytdriqvlrnmvhca
dlsnptkslelyrqwtdrimeeffqqgdkerergmeispmcdkhtasveksqvgfidyiv
hplwetwadlvqpdaqdildtlednrnwyqsmipqlmekfqf

Timeline for d4nw7a1:

• d4nw7a1 first appeared in SCOPe 2.04, called d4nw7a_
  
• d4nw7a1 was called d4nw7a_ in SCOPe 2.05
  
• d4nw7a1 appears in SCOPe 2.07
  
• d4nw7a1 appears in the current release, SCOPe 2.08