SCOPe 2.04: Domain d4nw7a_: 4nw7 A:

Lineage for d4nw7a_ (4nw7 A:)

1. Root: SCOPe 2.04

2. Class a: All alpha proteins [46456] (285 folds)

3. Fold a.211: HD-domain/PDEase-like [109603] (1 superfamily)
   multihelical; consists of two different alpha-helical bundles

4. Superfamily a.211.1: HD-domain/PDEase-like [109604] (6 families)

5. Family a.211.1.2: PDEase [48548] (7 proteins)
   Pfam PF00233; multihelical; can be divided into three subdomains

6. Protein automated matches [190370] (1 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187208] (23 PDB entries)

8. Domain d4nw7a_: 4nw7 A: [260343]
   automated match to d3hmva_
   complexed with 2o5, edo, mg, na, zn

Details for d4nw7a_

PDB Entry: 4nw7, 2.15 Å

PDB Description: PDE4 catalytic domain

PDB Compounds: (A:) cAMP-specific 3',5'-cyclic phosphodiesterase 4B

SCOPe Domain Sequences for d4nw7a_:

Sequence, based on SEQRES records:

>d4nw7a_ a.211.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
hmsisrfgvntenedhlakeledlnkwglnifnvagyshnrpltcimyaifqerdllktf
rissdtfitymmtledhyhsdvayhnslhaadvaqsthvllstpaldavftdleilaaif
aaaihdvdhpgvsnqflintnselalmyndesvlenhhlavgfkllqeehcdifmnltkk
qrqtlrkmvidmvlatdmskhmslladlktmvetkkvtssgvllldnytdriqvlrnmvh
cadlsnptkslelyrqwtdrimeeffqqgdkerergmeispmcdkhtasveksqvgfidy
ivhplwetwadlvqpdaqdildtlednrnwyqsmipqspsppldeqnrdcqglmekfqf

Sequence, based on observed residues (ATOM records):

>d4nw7a_ a.211.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
hmsisrfgvntenedhlakeledlnkwglnifnvagyshnrpltcimyaifqerdllktf
rissdtfitymmtledhyhsdvayhnslhaadvaqsthvllstpaldavftdleilaaif
aaaihdvdhpgvsnqflintnselalmyndesvlenhhlavgfkllqeehcdifmnltkk
qrqtlrkmvidmvlatdmskhmslladlktmvetkkvtssgvllldnytdriqvlrnmvh
cadlsnptkslelyrqwtdrimeeffqqgdkerergmeispmcdkhtasveksqvgfidy
ivhplwetwadlvqpdaqdildtlednrnwyqsmipqlmekfqf

Timeline for d4nw7a_:

• d4nw7a_ is new in SCOPe 2.04-stable
  
• d4nw7a_ appears in SCOPe 2.05
  
• d4nw7a_ appears in the current release, SCOPe 2.08, called d4nw7a1