SCOPe 2.08: Domain d4igha_: 4igh A:

Lineage for d4igha_ (4igh A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (34 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.4: FMN-linked oxidoreductases [51395] (2 families)

5. Family c.1.4.1: FMN-linked oxidoreductases [51396] (19 proteins)

6. Protein Dihydroorotate dehydrogenase [51397] (8 species)

7. Species Human (Homo sapiens) [TaxId:9606] [51400] (69 PDB entries)

8. Domain d4igha_: 4igh A: [223164]
   automated match to d1uuoa_
   complexed with 1ea, fmn, gol, oro, zwi
   has additional subdomain(s) that are not in the common domain
   has additional insertions and/or extensions that are not grouped together

Details for d4igha_

PDB Entry: 4igh, 1.3 Å

PDB Description: High resolution crystal structure of human dihydroorotate dehydrogenase bound with 4-quinoline carboxylic acid analog

PDB Compounds: (A:) Dihydroorotate dehydrogenase (quinone), mitochondrial

SCOPe Domain Sequences for d4igha_:

Sequence, based on SEQRES records:

>d4igha_ c.1.4.1 (A:) Dihydroorotate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
derfyaehlmptlqglldpesahrlavrftslgllprarfqdsdmlevrvlghkfrnpvg
iaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfnshg
lsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvvnv
sspntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvvk
elgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiigv
ggvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaigad
hrr

Sequence, based on observed residues (ATOM records):

>d4igha_ c.1.4.1 (A:) Dihydroorotate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
derfyaehlmptlqglldpesahrlavrftslgllprqdsdmlevrvlghkfrnpvgiaa
gfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfnshglsv
vehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvvnvssp
ntaglgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvvkelgidgl
ivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiigvggvssgq
dalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaigadhrr

Timeline for d4igha_:

• d4igha_ first appeared in SCOPe 2.03
  
• d4igha_ appears in SCOPe 2.07