Lineage for d4igha_ (4igh A:)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2078560Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
    contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
    the first seven superfamilies have similar phosphate-binding sites
  4. 2080000Superfamily c.1.4: FMN-linked oxidoreductases [51395] (2 families) (S)
  5. 2080001Family c.1.4.1: FMN-linked oxidoreductases [51396] (19 protein domains)
  6. 2080046Protein Dihydroorotate dehydrogenase [51397] (8 species)
  7. 2080052Species Human (Homo sapiens) [TaxId:9606] [51400] (43 PDB entries)
  8. 2080053Domain d4igha_: 4igh A: [223164]
    automated match to d1uuoa_
    complexed with 1ea, fmn, gol, oro, zwi

Details for d4igha_

PDB Entry: 4igh (more details), 1.3 Å

PDB Description: High resolution crystal structure of human dihydroorotate dehydrogenase bound with 4-quinoline carboxylic acid analog
PDB Compounds: (A:) Dihydroorotate dehydrogenase (quinone), mitochondrial

SCOPe Domain Sequences for d4igha_:

Sequence, based on SEQRES records: (download)

>d4igha_ c.1.4.1 (A:) Dihydroorotate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
derfyaehlmptlqglldpesahrlavrftslgllprarfqdsdmlevrvlghkfrnpvg
iaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfnshg
lsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvvnv
sspntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvvk
elgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiigv
ggvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaigad
hrr

Sequence, based on observed residues (ATOM records): (download)

>d4igha_ c.1.4.1 (A:) Dihydroorotate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
derfyaehlmptlqglldpesahrlavrftslgllprqdsdmlevrvlghkfrnpvgiaa
gfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfnshglsv
vehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvvnvssp
ntaglgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvvkelgidgl
ivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiigvggvssgq
dalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaigadhrr

SCOPe Domain Coordinates for d4igha_:

Click to download the PDB-style file with coordinates for d4igha_.
(The format of our PDB-style files is described here.)

Timeline for d4igha_: