Lineage for d3ml8a3 (3ml8 A:525-725)

  1. Root: SCOPe 2.06
  2. 1976409Class a: All alpha proteins [46456] (289 folds)
  3. 2006336Fold a.118: alpha-alpha superhelix [48370] (25 superfamilies)
    multihelical; 2 (curved) layers: alpha/alpha; right-handed superhelix
  4. 2006337Superfamily a.118.1: ARM repeat [48371] (26 families) (S)
  5. 2006533Family a.118.1.6: Phoshoinositide 3-kinase (PI3K) helical domain [48399] (1 protein)
    automatically mapped to Pfam PF00613
  6. 2006534Protein Phoshoinositide 3-kinase (PI3K) helical domain [48400] (2 species)
  7. 2006535Species Human (Homo sapiens) [TaxId:9606] [48402] (59 PDB entries)
  8. 2006592Domain d3ml8a3: 3ml8 A:525-725 [213320]
    Other proteins in same PDB: d3ml8a1, d3ml8a2, d3ml8a4
    automated match to d1e8ya1
    complexed with ml8

Details for d3ml8a3

PDB Entry: 3ml8 (more details), 2.7 Å

PDB Description: Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04691502 through Structure Based Drug Design
PDB Compounds: (A:) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d3ml8a3:

Sequence, based on SEQRES records: (download)

>d3ml8a3 a.118.1.6 (A:525-725) Phoshoinositide 3-kinase (PI3K) helical domain {Human (Homo sapiens) [TaxId: 9606]}

Sequence, based on observed residues (ATOM records): (download)

>d3ml8a3 a.118.1.6 (A:525-725) Phoshoinositide 3-kinase (PI3K) helical domain {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d3ml8a3:

Click to download the PDB-style file with coordinates for d3ml8a3.
(The format of our PDB-style files is described here.)

Timeline for d3ml8a3: