Lineage for d3ml8a2 (3ml8 A:357-522)

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2038038Fold b.7: C2 domain-like [49561] (5 superfamilies)
    sandwich; 8 strands in 2 sheets; greek-key
  4. 2038039Superfamily b.7.1: C2 domain (Calcium/lipid-binding domain, CaLB) [49562] (3 families) (S)
    two constituent families are related by circular permutation
  5. 2038040Family b.7.1.1: PLC-like (P variant) [49563] (12 protein domains)
  6. 2038063Protein Phoshoinositide 3-kinase (PI3K) [49570] (2 species)
  7. 2038064Species Human (Homo sapiens) [TaxId:9606] [49572] (58 PDB entries)
  8. 2038120Domain d3ml8a2: 3ml8 A:357-522 [213319]
    Other proteins in same PDB: d3ml8a1, d3ml8a3, d3ml8a4
    automated match to d1e8ya2
    complexed with ml8

Details for d3ml8a2

PDB Entry: 3ml8 (more details), 2.7 Å

PDB Description: Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04691502 through Structure Based Drug Design
PDB Compounds: (A:) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d3ml8a2:

Sequence, based on SEQRES records: (download)

>d3ml8a2 b.7.1.1 (A:357-522) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}

Sequence, based on observed residues (ATOM records): (download)

>d3ml8a2 b.7.1.1 (A:357-522) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d3ml8a2:

Click to download the PDB-style file with coordinates for d3ml8a2.
(The format of our PDB-style files is described here.)

Timeline for d3ml8a2: