SCOPe 2.08: Domain d2xwya_: 2xwy A:

Lineage for d2xwya_ (2xwy A:)

1. Root: SCOPe 2.08

2. Class e: Multi-domain proteins (alpha and beta) [56572] (74 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (9 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.4: RNA-dependent RNA-polymerase [56694] (3 proteins)

6. Protein automated matches [190260] (25 species)
   not a true protein

7. Species Hepatitis C virus [TaxId:11103] [187048] (44 PDB entries)

8. Domain d2xwya_: 2xwy A: [207371]
   automated match to d4e78a_
   complexed with ib8, mn

Details for d2xwya_

PDB Entry: 2xwy, 2.53 Å

PDB Description: structure of mk-3281, a potent non-nucleoside finger-loop inhibitor, in complex with the hepatitis c virus ns5b polymerase

PDB Compounds: (A:) RNA-directed RNA polymerase

SCOPe Domain Sequences for d2xwya_:

Sequence, based on SEQRES records:

>d2xwya_ e.8.1.4 (A:) automated matches {Hepatitis C virus [TaxId: 11103]}
smsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
svwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiy
qccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkas
aacraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspg
einrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavk

Sequence, based on observed residues (ATOM records):

>d2xwya_ e.8.1.4 (A:) automated matches {Hepatitis C virus [TaxId: 11103]}
smsytwtgalitpcmvyattsrsaglrqkkvtfdrlqvlddhyrdvlkemkakastvkak
llsveeackltpphsakskfgygakdvrnlsskavnhihsvwkdlledtvtpidttimak
nevfcvqpgrkparlivfpdlgvrvcekmalydvvstlpqvvmgssygfqyspgqrvefl
vntwkskknpmgfsydtrcfdstvtendirveesiyqccdlapearqaikslterlyigg
pltnskgqncgyrrcrasgvlttscgntltcylkasaacraaklqdctmlvngddlvvic
esagtqedaaslrvfteamtrysappgdppqpeydlelitscssnvsvahdasgkrvyyl
trdpttplaraawetarhtpvnswlgniimyaptlwarmilmthffsillaqeqlekald
cqiygacysiepldlpqiierlhglsafslhsyspgeinrvasclrklgvpplrvwrhra
rsvrarllsqggraatcgkylfnwavk

Timeline for d2xwya_:

• d2xwya_ first appeared in SCOPe 2.03
  
• d2xwya_ appears in SCOPe 2.07