PDB entry 2xwy

View 2xwy on RCSB PDB site
Description: Structure of MK-3281, a Potent Non-Nucleoside Finger-Loop Inhibitor, in complex with the Hepatitis C Virus NS5B Polymerase
Class: transferase
Keywords: transferase, allosteric inhibitor, nucleotidyltransferase
Deposited on 2010-11-06, released 2010-12-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-04-03, with a file datestamp of 2019-03-29.
Experiment type: XRAY
Resolution: 2.53 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: RNA-directed RNA polymerase
    Species: HEPATITIS C VIRUS [TaxId:11103]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2xwya_
  • Heterogens: IB8, MN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2xwyA (A:)
msmsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqv
lddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhi
hsvwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvv
stlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesi
yqccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylka
saacraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeyd
lelitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptl
warmilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsysp
geinrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkl

    Sequence, based on observed residues (ATOM records): (download) 
    >2xwyA (A:)
smsytwtgalitpcmvyattsrsaglrqkkvtfdrlqvlddhyrdvlkemkakastvkak
llsveeackltpphsakskfgygakdvrnlsskavnhihsvwkdlledtvtpidttimak
nevfcvqpgrkparlivfpdlgvrvcekmalydvvstlpqvvmgssygfqyspgqrvefl
vntwkskknpmgfsydtrcfdstvtendirveesiyqccdlapearqaikslterlyigg
pltnskgqncgyrrcrasgvlttscgntltcylkasaacraaklqdctmlvngddlvvic
esagtqedaaslrvfteamtrysappgdppqpeydlelitscssnvsvahdasgkrvyyl
trdpttplaraawetarhtpvnswlgniimyaptlwarmilmthffsillaqeqlekald
cqiygacysiepldlpqiierlhglsafslhsyspgeinrvasclrklgvpplrvwrhra
rsvrarllsqggraatcgkylfnwavk