SCOPe 2.08: Domain d2fgwh1: 2fgw H:1-124

Lineage for d2fgwh1 (2fgw H:1-124)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 proteins)

6. Protein Immunoglobulin heavy chain variable domain, VH [88543] (22 species)
   VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Engineered (including hybrid species) [88562] (67 PDB entries)
   SQ NA # humanized antidoby; bactericidal Fab-h6831 ! SQ NA # humanized antibody ! SQ NA # Humanized antibody ! SQ NA # engineered antibody

8. Domain d2fgwh1: 2fgw H:1-124 [19855]
   Other proteins in same PDB: d2fgwh2, d2fgwl1, d2fgwl2
   part of humanized Fab H52

Details for d2fgwh1

PDB Entry: 2fgw, 3 Å

PDB Description: x-ray structures of fragments from binding and nonbinding versions of a humanized anti-cd18 antibody: structural indications of the key role of vh residues 59 to 65

PDB Compounds: (H:) h52 fab (heavy chain)

SCOPe Domain Sequences for d2fgwh1:

Sequence, based on SEQRES records:

>d2fgwh1 b.1.1.1 (H:1-124) Immunoglobulin heavy chain variable domain, VH {Engineered (including hybrid species)}
evqlvesggglvqpggslrlscatsgytfteytmhwmrqapgkglewvaginpknggtsh
nqrfmdrftisvdkststaymqmnslraedtavyycarwrglnygfdvryfdvwgqgtlv
tvss

Sequence, based on observed residues (ATOM records):

>d2fgwh1 b.1.1.1 (H:1-124) Immunoglobulin heavy chain variable domain, VH {Engineered (including hybrid species)}
evqlvesggglvqpggslrlscatsgytfteytmhwmrqapgkglewvaginpknggtsh
nqrfmdrftisvdkststaymqmnslraedtavyycarwrryfdvwgqgtlvtvss

Timeline for d2fgwh1:

• d2fgwh1 first appeared (with stable ids) in SCOP 1.55
  
• d2fgwh1 appears in SCOPe 2.07