SCOPe 2.07: Domain d3hptd_: 3hpt D:

Lineage for d3hptd_ (3hpt D:)

1. Root: SCOPe 2.07

2. Class b: All beta proteins [48724] (178 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (49 proteins)

6. Protein Coagulation factor Xa, protease domain [50574] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50575] (57 PDB entries)
   Uniprot P00742 235-467

8. Domain d3hptd_: 3hpt D: [191883]
   Other proteins in same PDB: d3hpta1, d3hpta2, d3hptb_, d3hptc1, d3hptc2
   automated match to d1c5md_
   complexed with act, ca, dms, gol, mes, na, yet

Details for d3hptd_

PDB Entry: 3hpt, 2.19 Å

PDB Description: crystal structure of human fxa in complex with (s)-2-cyano-1-(2- methylbenzofuran-5-yl)-3-(2-oxo-1-(2-oxo-2-(pyrrolidin-1-yl)ethyl) azepan-3-yl)guanidine

PDB Compounds: (D:) coagulation factor x

SCOPe Domain Sequences for d3hptd_:

Sequence, based on SEQRES records:

>d3hptd_ b.47.1.2 (D:) Coagulation factor Xa, protease domain {Human (Homo sapiens) [TaxId: 9606]}
ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
tqktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmktrglp

Sequence, based on observed residues (ATOM records):

>d3hptd_ b.47.1.2 (D:) Coagulation factor Xa, protease domain {Human (Homo sapiens) [TaxId: 9606]}
ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
tqktgivsgfgrthegrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqedac
qgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmktrglp

Timeline for d3hptd_:

• d3hptd_ first appeared in SCOPe 2.02
  
• d3hptd_ appears in SCOPe 2.06
  
• d3hptd_ appears in the current release, SCOPe 2.08