SCOPe 2.01: Domain d3n84e_: 3n84 E:

Lineage for d3n84e_ (3n84 E:)

1. Root: SCOPe 2.01

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.93: SH2-like [55549] (1 superfamily)
   3 layers: a/b/a; antiparallel beta-sheet of 5 strands is flaked by two helices

4. Superfamily d.93.1: SH2 domain [55550] (2 families)

5. Family d.93.1.1: SH2 domain [55551] (35 proteins)
   Pfam PF00017

6. Protein Growth factor receptor-bound protein 2 (GRB2) [55563] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [55564] (31 PDB entries)

8. Domain d3n84e_: 3n84 E: [182015]
   automated match to d1fhsa_
   complexed with cl, gol, mg

Details for d3n84e_

PDB Entry: 3n84, 2 Å

PDB Description: Crystal Structure of the Grb2 SH2 Domain in Complex with a 23-Membered Macrocyclic Ligand Having the Sequence pYVNVP

PDB Compounds: (E:) Growth factor receptor-bound protein 2

SCOPe Domain Sequences for d3n84e_:

Sequence; same for both SEQRES and ATOM records:

>d3n84e_ d.93.1.1 (E:) Growth factor receptor-bound protein 2 (GRB2) {Human (Homo sapiens) [TaxId: 9606]}
miemkphpwffgkiprakaeemlskqrhdgafliresesapgdfslsvkfgndvqhfkvl
rdgagkyflwvvkfnslnelvdyhrstsvsrnqqiflrdieq

Timeline for d3n84e_:

• d3n84e_ is new in SCOPe 2.01-stable
  
• d3n84e_ appears in SCOPe 2.02
  
• d3n84e_ appears in the current release, SCOPe 2.08, called d3n84e1