Lineage for Family d.93.1.1: SH2 domain

  1. Root: SCOPe 2.01
  2. 1013083Class d: Alpha and beta proteins (a+b) [53931] (376 folds)
  3. 1035347Fold d.93: SH2-like [55549] (1 superfamily)
    3 layers: a/b/a; antiparallel beta-sheet of 5 strands is flaked by two helices
  4. 1035348Superfamily d.93.1: SH2 domain [55550] (2 families) (S)
  5. 1035349Family d.93.1.1: SH2 domain [55551] (35 proteins)
    Pfam PF00017

Proteins:

  1. 1035350Abl tyrosine kinase [55581] (2 species)
    1. 1035351Species Human (Homo sapiens) [TaxId:9606] [55582] (1 PDB entry)
    2. 1035353Species Mouse (Mus musculus) [TaxId:10090] [89998] (2 PDB entries)
  2. 1035357Adaptor protein Aps [103139] (1 species)
  3. 1035363Beta-chimaerin, N-terminal domain [118052] (1 species)
    includes N-terminal tail and the linker to the next domain
  4. 1035366c-src tyrosine kinase [55556] (3 species)
    1. 1035367Species Chicken (Gallus gallus) [TaxId:9031] [55558] (3 PDB entries)
    2. 1035371Species Human (Homo sapiens) [TaxId:9606] [55557] (42 PDB entries)
    3. 1035421Species Rous sarcoma virus [TaxId:11886] [69782] (13 PDB entries)
  5. 1035444Carboxyl-terminal src kinase (csk) [75498] (1 species)
  6. 1035452Cbl [55587] (1 species)
  7. 1035468Crk proto-oncogen [82741] (1 species)
  8. 1035473Csk homologous kinase Chk [64345] (1 species)
  9. 1035477Ews/fli1 activated transcript 2, Eat2 [89999] (1 species)
  10. 1035480GRB2-related adaptor protein 2 (MONA, GRID) [111086] (1 species)
  11. 1035492Growth factor receptor-bound protein 10, GRB10 [89994] (1 species)
  12. 1035496Growth factor receptor-bound protein 2 (GRB2) [55563] (1 species)
  13. 1035559Growth factor receptor-bound protein 7 [103135] (1 species)
  14. 1035566Hematopoietic SH2 domain containing protein HSH2D [143623] (1 species)
  15. 1035569Hemopoetic cell kinase Hck [55565] (1 species)
  16. 1035577Itk/tsk protein tyrosine kinase [82743] (1 species)
  17. 1035585P55 Blk protein tyrosine kinase [55579] (1 species)
  18. 1035589p56-lck tyrosine kinase [55552] (1 species)
  19. 1035610Phosphatidylinositol 3-kinase, p85-alpha subunit [55569] (3 species)
    1. 1035611Species Cow (Bos taurus) [TaxId:9913] [55570] (7 PDB entries)
    2. 1035619Species Human (Homo sapiens) [TaxId:9606] [55571] (2 PDB entries)
    3. 1035622Species Norway rat (Rattus norvegicus) [TaxId:10116] [55572] (2 PDB entries)
  20. 1035625Phospholipase C-gamma-1 [55577] (1 species)
  21. 1035630Proto-oncogen tyrosine kinase [55573] (1 species)
  22. 1035634Shc adaptor protein [55567] (1 species)
  23. 1035638STAT homologue [103137] (1 species)
  24. 1035642STAT-1 [55583] (1 species)
  25. 1035645STAT3b [55585] (1 species)
  26. 1035648Suppressor of cytokine signaling 2, SOCS-2 [160562] (1 species)
  27. 1035651Suppressor of cytokine signaling 4, SOCS-4 [160564] (1 species)
  28. 1035654Syk tyrosine kinase [55575] (1 species)
  29. 1035670The Xlp protein Sap [55591] (1 species)
  30. 1035682Tyrosine kinase Fyn [55559] (1 species)
  31. 1035688Tyrosine phoshatase shp-2 [55589] (1 species)
  32. 1035694Tyrosine phosphatase Syp [55561] (1 species)
  33. 1035701Tyrosine-protein kinase 6 (Breast tumor kinase, Brk) [111084] (1 species)
  34. 1035704Tyrosine-protein kinase zap-70 [89996] (1 species)
  35. 1035710automated matches [190202] (2 species)
    not a true protein
    1. 1035711Species Human (Homo sapiens) [TaxId:9606] [186949] (6 PDB entries)
    2. 1035719Species Mouse (Mus musculus) [TaxId:10090] [187800] (3 PDB entries)

More info for Family d.93.1.1: SH2 domain

Timeline for Family d.93.1.1: SH2 domain: