SCOPe 2.08: Domain d3k65b_: 3k65 B:

Lineage for d3k65b_ (3k65 B:)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (49 proteins)

6. Protein Thrombin [50531] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50532] (171 PDB entries)
   Uniprot P00734 331-361,364-421 ! Uniprot P00734 334-360 364-510 518-619 ! Uniprot P00734 328-620 ! Uniprot P00734 355-621 ! Uniprot P00734 328-620

8. Domain d3k65b_: 3k65 B: [179109]
   Other proteins in same PDB: d3k65a_
   automated match to d1doja_
   complexed with bu1

Details for d3k65b_

PDB Entry: 3k65, 1.85 Å

PDB Description: crystal structure of prethombin-2/fragment-2 complex

PDB Compounds: (B:) Prothrombin

SCOPe Domain Sequences for d3k65b_:

Sequence, based on SEQRES records:

>d3k65b_ b.47.1.2 (B:) Thrombin {Human (Homo sapiens) [TaxId: 9606]}
tffnprtfgsgeadcglrplfekksledkterellesyidgrivegsdaeigmspwqvml
frkspqellcgaslisdrwvltaahcllyppwdknftendllvrigkhsrtryernieki
smlekiyihprynwrenldrdialmklkkpvafsdyihpvclpdretaasllqagykgrv
tgwgnlketwtanvgkgqpsvlqvvnlpiverpvckdstriritdnmfcagykpdegkrg
dacegdaggpfvmkspfnnrwyqmgivswgegcdrdgkygfythvfrlkkwiqkvidqf

Sequence, based on observed residues (ATOM records):

>d3k65b_ b.47.1.2 (B:) Thrombin {Human (Homo sapiens) [TaxId: 9606]}
tffnprtfgsgeadcglrplfekksledkterellesyidgrivegsdaeigmspwqvml
frkspqellcgaslisdrwvltaahcllyppwdknftendllvrigkhsrtryernieki
smlekiyihprynwrenldrdialmklkkpvafsdyihpvclpdretaasllqagykgrv
tgwqpsvlqvvnlpiverpvckdstriritdnmfcagykpdgdaggpfvmkspfnnrwyq
mgivswgcdrdgkygfythvfrlkkwiqkvidqf

Timeline for d3k65b_:

• d3k65b_ first appeared in SCOPe 2.01
  
• d3k65b_ appears in SCOPe 2.07