SCOPe 2.06: Domain d1nfoa_: 1nfo A:

Lineage for d1nfoa_ (1nfo A:)

1. Root: SCOPe 2.06

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.24: Four-helical up-and-down bundle [47161] (28 superfamilies)
   core: 4 helices; bundle, closed or partly opened, left-handed twist; up-and-down

4. Superfamily a.24.1: Apolipoprotein [47162] (1 family)

5. Family a.24.1.1: Apolipoprotein [47163] (1 protein)
   Can exist in a coiled-coil oligomeric form, see PDB entry 1AV1
   family may also include the five-helical bundle protein Apolipophorin-III

6. Protein Apolipoprotein E [88703] (3 species)

7. Species Human (Homo sapiens), E2 [TaxId:9606] [47167] (2 PDB entries)

8. Domain d1nfoa_: 1nfo A: [16526]
   mutant

Details for d1nfoa_

PDB Entry: 1nfo, 2 Å

PDB Description: apolipoprotein e2 (apoe2, d154a mutation)

PDB Compounds: (A:) apolipoprotein e2

SCOPe Domain Sequences for d1nfoa_:

Sequence, based on SEQRES records:

>d1nfoa_ a.24.1.1 (A:) Apolipoprotein E {Human (Homo sapiens), E2 [TaxId: 9606]}
gqrwelalgrfwdylrwvqtlseqvqeellssqvtqelralmdetmkelkaykseleeql
tpvaeetrarlskelqaaqarlgadmedvcgrlvqyrgevqamlgqsteelrvrlashlr
klrkrllrdadalqkclavyq

Sequence, based on observed residues (ATOM records):

>d1nfoa_ a.24.1.1 (A:) Apolipoprotein E {Human (Homo sapiens), E2 [TaxId: 9606]}
gqrwelalgrfwdylrwvqtlseqvqeellssqvtqelralmdetmkelkaykseleeqr
lskelqaaqarlgadmedvcgrlvqyrgevqamlgqsteelrvrlashlrklrkrllrda
dalqkclavyq

Timeline for d1nfoa_:

• d1nfoa_ first appeared (with stable ids) in SCOP 1.55, called d1nfo__
  
• d1nfoa_ appears in SCOPe 2.05
  
• d1nfoa_ appears in SCOPe 2.07
  
• d1nfoa_ appears in the current release, SCOPe 2.08