SCOPe 2.07: Domain d1jr1a4: 1jr1 A:113-232

Lineage for d1jr1a4 (1jr1 A:113-232)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.37: CBS-domain pair [54630] (1 superfamily)
   duplication: tandem repeat of two beta-X-beta-alpha-beta(2)-alpha motifs of similar sequences; 4 layers: a/b/b/a

4. Superfamily d.37.1: CBS-domain pair [54631] (2 families)

5. Family d.37.1.1: CBS-domain pair [54632] (21 proteins)
   Pfam PF00571; pairs of CBS domains dimerize to form a stable globular domain, a.k.a. Bateman domain

6. Protein Type II inosine monophosphate dehydrogenase CBS domains [54633] (4 species)
   contains tandem repeat of two CBS domains inserted into the catalytic TIM-barrel domain; may be disordered in the crystals

7. Species Chinese hamster (Cricetulus griseus) [TaxId:10029] [64260] (1 PDB entry)

8. Domain d1jr1a4: 1jr1 A:113-232 [144358]
   Other proteins in same PDB: d1jr1a1, d1jr1b1
   complexed with imp, k, moa

Details for d1jr1a4

PDB Entry: 1jr1, 2.6 Å

PDB Description: crystal structure of inosine monophosphate dehydrogenase in complex with mycophenolic acid

PDB Compounds: (A:) Inosine-5'-monophosphate dehydrogenase 2

SCOPe Domain Sequences for d1jr1a4:

Sequence, based on SEQRES records:

>d1jr1a4 d.37.1.1 (A:113-232) Type II inosine monophosphate dehydrogenase CBS domains {Chinese hamster (Cricetulus griseus) [TaxId: 10029]}
gfitdpvvlspkdrvrdvfeakarhgfcgipitdtgrmgsrlvgiissrdidflkeeehd
rfleeimtkredlvvapagitlkeaneilqrskkgklpivnendelvaiiartdlkknrd

Sequence, based on observed residues (ATOM records):

>d1jr1a4 d.37.1.1 (A:113-232) Type II inosine monophosphate dehydrogenase CBS domains {Chinese hamster (Cricetulus griseus) [TaxId: 10029]}
gfitdpvvdrvrfeakmgsrlvimtkredlvvapagitlkeaneilqrsklpivnendel
vaiiartdlkknrd

Timeline for d1jr1a4:

• d1jr1a4 first appeared in SCOP 1.75
  
• d1jr1a4 appears in SCOPe 2.06
  
• d1jr1a4 appears in the current release, SCOPe 2.08