SCOPe 2.04: Domain d2p2ia_: 2p2i A:

Lineage for d2p2ia_ (2p2i A:)

1. Root: SCOPe 2.04

2. Class d: Alpha and beta proteins (a+b) [53931] (380 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Vascular endothelial growth factor receptor 2 (kdr) [56160] (1 species)
   PTK group; PDGFR/VEGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56161] (20 PDB entries)

8. Domain d2p2ia_: 2p2i A: [139463]
   automated match to d1vr2a_
   complexed with 608

Details for d2p2ia_

PDB Entry: 2p2i, 2.4 Å

PDB Description: crystal structure of the vegfr2 kinase domain in complex with a nicotinamide inhibitor

PDB Compounds: (A:) Vascular endothelial growth factor receptor 2

SCOPe Domain Sequences for d2p2ia_:

Sequence, based on SEQRES records:

>d2p2ia_ d.144.1.7 (A:) Vascular endothelial growth factor receptor 2 (kdr) {Human (Homo sapiens) [TaxId: 9606]}
aerlpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvavkmlkegath
sehralmselkilihighhlnvvnllgactkpggplmvivefckfgnlstylrskrnefv
pykvapedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvkicd
fglardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweifslgaspy
pgvkideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnllqa
naqqdrhhhhhh

Sequence, based on observed residues (ATOM records):

>d2p2ia_ d.144.1.7 (A:) Vascular endothelial growth factor receptor 2 (kdr) {Human (Homo sapiens) [TaxId: 9606]}
aerlpydaskwefprdrlklgkplgrgafgqvieadafgidtcrtvavkmlthsehralm
selkilihighhlnvvnllgactkpggplmvivefckfgnlstylrskrnefvpykvape
dlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvkicdfglalpl
kwmapetifdrvytiqsdvwsfgvllweifslgaspypgvkideefcrrlkegtrmrapd
yttpemyqtmldcwhgepsqrptfselvehlgnllqanaqqdrhhhhhh

Timeline for d2p2ia_:

• d2p2ia_ first appeared in SCOP 1.73, called d2p2ia1
  
• d2p2ia_ appears in SCOPe 2.03
  
• d2p2ia_ appears in SCOPe 2.05
  
• d2p2ia_ appears in the current release, SCOPe 2.08, called d2p2ia2