SCOPe 2.08: Domain d2isic_: 2isi C:

Lineage for d2isic_ (2isi C:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.151: DNase I-like [56218] (1 superfamily)
   contains beta-sandwich; duplication of alpha+beta motif

4. Superfamily d.151.1: DNase I-like [56219] (4 families)

5. Family d.151.1.1: DNase I-like [56220] (7 proteins)

6. Protein automated matches [190454] (2 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187368] (6 PDB entries)

8. Domain d2isic_: 2isi C: [137605]
   automated match to d2o3ha_
   complexed with mg, po4

Details for d2isic_

PDB Entry: 2isi, 2.76 Å

PDB Description: Crystal structure of Ape1 from Homo sapiens in a new crystal form complexed with a ligand

PDB Compounds: (C:) DNA-(apurinic or apyrimidinic site) lyase

SCOPe Domain Sequences for d2isic_:

Sequence, based on SEQRES records:

>d2isic_ d.151.1.1 (C:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
alyedppdqktspsgkpatlkicswnvdglrawikkkgldwvkeeapdilclqetkcsen
klpaelqelpglshqywsapsdkegysgvgllsrqcplkvsygigdeehdqegrvivaef
dsfvlvtayvpnagrglvrleyrqrwdeafrkflkglasrkplvlcgdlnvaheeidlrn
pkgnkknagftpqerqgfgellqavpladsfrhlypntpyaytfwtymmnarsknvgwrl
dyfllshsllpalcdskirskalgsdhcpitlylal

Sequence, based on observed residues (ATOM records):

>d2isic_ d.151.1.1 (C:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
alyedppdqktspsgkpatlkicswnvdglrawikkkgldwvkeeapdilclqetkcsen
klpaelqelpglshqywsapegysgvgllsrqcplkvsygigdeehdqegrvivaefdsf
vlvtayvpnagrglvrleyrqrwdeafrkflkglasrkplvlcgdlnvaheeidlrnpkg
nkknagftpqerqgfgellqavpladsfrhlypntpyaytfwtymmnarsknvgwrldyf
llshsllpalcdskirskalgsdhcpitlylal

Timeline for d2isic_:

• d2isic_ first appeared in SCOP 1.73, called d2isic1
  
• d2isic_ appears in SCOPe 2.07