SCOP 1.73: Domain d1xr3b1: 1xr3 B:6-261

Lineage for d1xr3b1 (1xr3 B:6-261)

1. Root: SCOP 1.73

2. Class c: Alpha and beta proteins (a/b) [51349] (141 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (70 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein beta-keto acyl carrier protein reductase [51788] (8 species)

7. Species Streptomyces coelicolor [TaxId:1902] [117408] (4 PDB entries)

8. Domain d1xr3b1: 1xr3 B:6-261 [122246]
   automatically matched to 1XR3 A:6-261
   complexed with isz, nap

Details for d1xr3b1

PDB Entry: 1xr3, 2.71 Å

PDB Description: Actinorhodin Polyketide Ketoreductase with NADP and the Inhibitor Isoniazid bound

PDB Compounds: (B:) Actinorhodin Polyketide Ketoreductase

SCOP Domain Sequences for d1xr3b1:

Sequence, based on SEQRES records:

>d1xr3b1 c.2.1.2 (B:6-261) beta-keto acyl carrier protein reductase {Streptomyces coelicolor [TaxId: 1902]}
sevalvtgatsgigleiarrlgkeglrvfvcargeeglrttlkelreagveadgrtcdvr
svpeiealvaavverygpvdvlvnnagrpgggataeladelwldvvetnltgvfrvtkqv
lkaggmlergtgrivniastggkqgvvhaapysaskhgvvgftkalglelartgitvnav
cpgfvetpmaasvrehysdiwevsteeafdritarvpigryvqpsevaemvayligpgaa
avtaqalnvcgglgny

Sequence, based on observed residues (ATOM records):

>d1xr3b1 c.2.1.2 (B:6-261) beta-keto acyl carrier protein reductase {Streptomyces coelicolor [TaxId: 1902]}
sevalvtgatsgigleiarrlgkeglrvfvcargeeglrttlkelreagveadgrtcdvr
svpeiealvaavverygpvdvlvnnagrpgggataeladelwldvvetnltgvfrvtkqv
lkaggmlergtgrivniastggkqgvvhaapysaskhgvvgftkalglelartgitvnav
cpgfvetpmaasvrevsteeafdritarvpigryvqpsevaemvayligpgaaavtaqal
nvcgglgny

Timeline for d1xr3b1:

• d1xr3b1 is new in SCOP 1.73
  
• d1xr3b1 appears in SCOP 1.75
  
• d1xr3b1 appears in the current release, SCOPe 2.08, called d1xr3b_