Lineage for Family c.2.1.2: Tyrosine-dependent oxidoreductases

  1. Root: SCOP 1.73
  2. 681097Class c: Alpha and beta proteins (a/b) [51349] (141 folds)
  3. 685975Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 685976Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families) (S)
  5. 686289Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (70 proteins)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

Proteins:

  1. 686290(3R)-hydroxyacyl-CoA dehydrogenase domain of estradiol 17 beta-Dehydrogenase 4 [82294] (1 species)
    peroxisomal multifunctional enzyme type 2
    segment swapping involving a C-terminal extension to the family fold
  2. 686296(s)-1-phenylethanol dehydrogenase [141902] (1 species)
  3. 6863041,3,6,8-tetrahydroxynaphthalene reductase [63929] (1 species)
  4. 6863071,3,8-trihydroxynaphtalene reductase (THNR, naphtol reductase) [51798] (1 species)
  5. 68631911-beta-hydroxysteroid dehydrogenase 1 [117423] (3 species)
    1. 686320Species Guinea pig (Cavia porcellus) [TaxId:10141] [117425] (1 PDB entry)
    2. 686323Species Human (Homo sapiens) [TaxId:9606] [117424] (4 PDB entries)
    3. 686344Species Mouse (Mus musculus) [TaxId:10090] [141879] (2 PDB entries)
  6. 68634915-hydroxyprostaglandin dehydrogenase, PGDH [141888] (1 species)
  7. 68635217-beta-hydroxysteroid dehydrogenase type XI [117426] (1 species)
  8. 6863562,4-dienoyl-CoA reductase, mitochondrial (DECR) [117421] (1 species)
  9. 6863703-alpha,20-beta-hydroxysteroid dehydrogenase [51776] (1 species)
  10. 6863803-alpha-hydroxysteroid dehydrogenase [51778] (1 species)
  11. 6863863beta/17beta hydroxysteroid dehydrogenase [82290] (1 species)
  12. 6863927-alpha-hydroxysteroid dehydrogenase [51774] (1 species)
  13. 686400ADP-L-glycero-D-mannoheptose 6-epimerase [51761] (1 species)
  14. 686412Aldehyde reductase II [117413] (1 species)
  15. 686420Bacterial sepiapterin reductase [141892] (1 species)
  16. 686426beta-keto acyl carrier protein reductase [51788] (8 species)
    1. 686427Species Escherichia coli [TaxId:562] [51790] (3 PDB entries)
    2. 686442Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [141877] (1 PDB entry)
    3. 686444Species Mycobacterium tuberculosis [TaxId:1773] [141875] (3 PDB entries)
    4. 686451Species Oil seed rape (Brassica napus) [TaxId:3708] [51789] (2 PDB entries)
    5. 686459Species Streptomyces coelicolor [TaxId:1902] [117408] (4 PDB entries)
    6. 686468Species Thermotoga maritima [TaxId:2336] [102150] (1 PDB entry)
      TM1169
    7. 686473Species Thermus thermophilus [TaxId:274] [117407] (1 PDB entry)
    8. 686482Species Thermus thermophilus, TTHB020 [TaxId:274] [141876] (1 PDB entry)
  17. 686485Biliverdin IX beta reductase [63931] (1 species)
    Histidine in the active site instead of the Tyr-Lys dyad
  18. 686492Carbonyl reductase [51765] (2 species)
    1. 686493Species Human (Homo sapiens) [TaxId:9606] [102144] (2 PDB entries)
      dicarbonyl/L-xylulose reductase
    2. 686500Species Mouse (Mus musculus) [TaxId:10090] [51766] (1 PDB entry)
  19. 686505Carbonyl reductase sniffer [110413] (1 species)
  20. 686508Carbonyl reductase/20beta-hydroxysteroid dehydrogenase [63935] (2 species)
    1. 686509Species Human (Homo sapiens) [TaxId:9606] [141878] (1 PDB entry)
    2. 686511Species Pig (Sus scrofa) [TaxId:9823] [63936] (1 PDB entry)
  21. 686513CDP-glucose-4,6-dehydratase [102136] (2 species)
    1. 686514Species Salmonella typhimurium [TaxId:90371] [141873] (1 PDB entry)
    2. 686517Species Yersinia pseudotuberculosis [TaxId:633] [102137] (1 PDB entry)
  22. 686522CDP-tyvelose-2-epimerase [102138] (1 species)
  23. 686528Cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase [51780] (1 species)
  24. 686531D(-)-3-hydroxybutyrate dehydrogenase [141886] (1 species)
  25. 686536Dehydrogenase/reductase SDR family member 6, DHRS6 [141894] (1 species)
    Oxidoreductase UCPA
  26. 686542Dihydropteridin reductase (pteridine reductase) [51769] (6 species)
    1. 686543Species Human (Homo sapiens) [TaxId:9606] [51771] (1 PDB entry)
    2. 686545Species Leishmania major [TaxId:5664] [63926] (8 PDB entries)
    3. 686580Species Leishmania tarentolae [TaxId:5689] [102145] (1 PDB entry)
    4. 686585Species Nematode (Caenorhabditis elegans) [TaxId:6239] [89520] (1 PDB entry)
    5. 686588Species Rat (Rattus norvegicus) [TaxId:10116] [51770] (2 PDB entries)
    6. 686594Species Trypanosoma cruzi [TaxId:5693] [102146] (2 PDB entries)
  27. 686603Drosophila alcohol dehydrogenase [51782] (2 species)
    1. 686604Species Fly (Drosophila lebanonensis) [TaxId:7225] [51783] (6 PDB entries)
    2. 686616Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [102147] (1 PDB entry)
  28. 686619DTDP-4-dehydrorhamnose reductase RfbD [110409] (1 species)
  29. 686624dTDP-6-deoxy-L-lyxo-4-hexulose reductase (RmlD) [75102] (1 species)
  30. 686630dTDP-glucose 4,6-dehydratase (RmlB) [51755] (4 species)
    1. 686631Species Escherichia coli [TaxId:562] [51756] (1 PDB entry)
    2. 686634Species Salmonella enterica [TaxId:28901] [63925] (1 PDB entry)
    3. 686639Species Streptococcus suis, serotype 2 [TaxId:1307] [69406] (6 PDB entries)
    4. 686652Species Streptomyces venezuelae [TaxId:54571] [102133] (2 PDB entries)
  31. 686655Enoyl-ACP reductase [51791] (6 species)
    1. 686656Species Escherichia coli [TaxId:562] [51794] (13 PDB entries)
    2. 686693Species Helicobacter pylori [TaxId:210] [102151] (2 PDB entries)
    3. 686702Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [82296] (11 PDB entries)
    4. 686727Species Mycobacterium tuberculosis, TB, gene InhA [TaxId:1773] [51793] (19 PDB entries)
    5. 686774Species Oil seed rape (Brassica napus) [TaxId:3708] [51792] (4 PDB entries)
    6. 686780Species Thermus thermophilus [TaxId:274] [117409] (2 PDB entries)
  32. 686793Erythromycin synthase, eryAI, 1st ketoreductase module [141909] (1 species)
    tandem repeat of two SDR-like modules resembling a dimer commonly founf in the family; only the second module retains the coenzyme-binding site
  33. 686799GDP-4-keto-6-deoxy-d-mannose epimerase/reductase (GDP-fucose synthetase) [51757] (1 species)
  34. 686809GDP-mannose 4,6-dehydratase [51759] (4 species)
    1. 686810Species Escherichia coli [TaxId:562] [51760] (1 PDB entry)
    2. 686812Species Human (Homo sapiens) [TaxId:9606] [102135] (1 PDB entry)
    3. 686817Species Pseudomonas aeruginosa [TaxId:287] [102134] (1 PDB entry)
    4. 686822Species Thale-cress (Arabidopsis thaliana) [TaxId:3702] [82289] (2 PDB entries)
  35. 686829GDP-mannose-3', 5'-epimerase [141890] (1 species)
  36. 686839Gluconate 5-dehydrogenase [110411] (1 species)
  37. 686843Glucose dehydrogenase [51784] (1 species)
  38. 686861Glucose dehydrogenase (5l265) [102155] (1 species)
  39. 686864Halohydrin dehalogenase HheC [102153] (1 species)
    haloalcohol dehalogenase: evolved a new activity; lost the NAD-binding site
  40. 686896Human estrogenic 17beta-hydroxysteroid dehydrogenase [51772] (1 species)
  41. 686921Hypothetical protein At5g02240 (T7H20_290) [117417] (1 species)
  42. 686931Hypothetical protein F25D1.5 [110415] (1 species)
  43. 686935Hypothetical protein PA4017 [141911] (1 species)
    unknown function; the active site region is blocked by a loop; strong sequence similarity to mammalian TAT-interacting protein TIP30
  44. 686939Hypothetical protein R05D8.7 [117415] (1 species)
  45. 686945Hypothetical protein TTHA0369 [141896] (1 species)
    TT0321
  46. 686951Levodione reductase [89523] (1 species)
  47. 686961Mannitol dehydrogenase [63927] (1 species)
  48. 686975meso-2,3-butanediol dehydrogenase [51786] (1 species)
  49. 686985Negative transcriptional regulator NmrA [69407] (1 species)
    has an UDP-galactose 4-epimerase-like structure but evolved a different function
  50. 686993Peroxisomal multifunctional enzyme type 2 [141900] (1 species)
    17-beta-hydroxysteroid dehydrogenase 4
  51. 687001Peroxisomal trans 2-enoyl CoA reductase [141884] (1 species)
  52. 687007Phenylcoumaran benzylic ether reductase [102140] (1 species)
  53. 687011Pinoresinol-lariciresinol reductase [102142] (1 species)
  54. 687017Polymyxin resistance protein ArnA (PrmI) [117419] (1 species)
    evolved new activities: UDP-glucuronic acid decarboxylase, UDP-4-amino-4-deoxy-L-arabinose formyltransferase
  55. 687031Putative carbonyl reductase sniffer [141913] (1 species)
  56. 687039Putative dehydrogenase ARPG836 (MGC4172) [117411] (1 species)
  57. 687045Putative oxidoreductase Rv2002 [82292] (1 species)
  58. 687057R-specific alcohol dehydrogenase [89521] (1 species)
  59. 687074Retinal dehydrogenase/reductase 3 [141907] (1 species)
  60. 687092Rhizome secoisolariciresinol dehydrogenase [141898] (1 species)
  61. 687098Sepiapterin reductase [51767] (2 species)
    1. 687099Species Human (Homo sapiens) [TaxId:9606] [141874] (1 PDB entry)
    2. 687106Species Mouse (Mus musculus) [TaxId:10090] [51768] (3 PDB entries)
  62. 687110Sorbitol dehydrogenase [102148] (1 species)
  63. 687114Sulfolipid biosynthesis protein SQD1 [51763] (1 species)
  64. 687120TAT-interacting protein TIP30 [141904] (2 species)
    1. 687121Species Human (Homo sapiens) [TaxId:9606] [141905] (1 PDB entry)
    2. 687123Species Mouse (Mus musculus) [TaxId:10090] [141906] (1 PDB entry)
  65. 687125Tropinone reductase [51795] (3 species)
    1. 687126Species Jimsonweed (Datura stramonium), I [TaxId:4076] [51796] (1 PDB entry)
    2. 687129Species Jimsonweed (Datura stramonium), II [TaxId:4076] [51797] (4 PDB entries)
    3. 687137Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [117410] (2 PDB entries)
  66. 687140Type II 3-hydroxyacyl-CoA dehydrogenase [63933] (3 species)
    1. 687141Species Human (Homo sapiens) [TaxId:9606] [102152] (3 PDB entries)
    2. 687149Species Rat (Rattus norvegicus) [TaxId:10116] [63934] (3 PDB entries)
    3. 687162Species Thermus thermophilus [TaxId:274] [89525] (1 PDB entry)
  67. 687165UDP-glucuronate decarboxylase 1 [141880] (1 species)
  68. 687168UDP-N-acetylglucosamine 4-epimerase WbpP [110407] (1 species)
  69. 687172Uridine diphosphogalactose-4-epimerase (UDP-galactose 4-epimerase) [51752] (4 species)
    1. 687173Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [141872] (1 PDB entry)
      N-terminal domain of bifunctional Gal10 protein
    2. 687175Species Escherichia coli [TaxId:562] [51753] (17 PDB entries)
    3. 687194Species Human (Homo sapiens) [TaxId:9606] [51754] (7 PDB entries)
    4. 687208Species Trypanosoma brucei [TaxId:5691] [89519] (2 PDB entries)
  70. 687217Xylitol dehydrogenase [141882] (1 species)

More info for Family c.2.1.2: Tyrosine-dependent oxidoreductases

Timeline for Family c.2.1.2: Tyrosine-dependent oxidoreductases: