Lineage for Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains

  1. Root: SCOP 1.73
  2. 681097Class c: Alpha and beta proteins (a/b) [51349] (141 folds)
  3. 685975Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 685976Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families) (S)

Families:

  1. 685977c.2.1.1: Alcohol dehydrogenase-like, C-terminal domain [51736] (16 protein domains)
    N-terminal all-beta domain defines family
  2. 686289c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (70 protein domains)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
  3. 687227c.2.1.3: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain [51800] (22 protein domains)
    family members also share a common alpha+beta fold in C-terminal domain
  4. 687750c.2.1.4: Formate/glycerate dehydrogenases, NAD-domain [51830] (10 protein domains)
    this domain interrupts the other domain which defines family
  5. 687902c.2.1.5: LDH N-terminal domain-like [51848] (8 protein domains)
  6. 688157c.2.1.6: 6-phosphogluconate dehydrogenase-like, N-terminal domain [51868] (17 protein domains)
    the beta-sheet is extended to 8 strands, order 32145678; strands 7 & 8 are antiparallel to the rest
    C-terminal domains also show some similarity
  7. 688318c.2.1.7: Aminoacid dehydrogenase-like, C-terminal domain [51883] (11 protein domains)
    extra N-terminal helix displaces the C-terminal helix (following strand 6) from its usual position creating a family nicotineamide-binding site
  8. 688570c.2.1.8: CoA-binding domain [51900] (5 protein domains)
  9. 688610c.2.1.9: Potassium channel NAD-binding domain [63944] (4 protein domains)
  10. 688655c.2.1.11: Siroheme synthase N-terminal domain-like [75110] (2 protein domains)
  11. 688669c.2.1.12: Transcriptional repressor Rex, C-terminal domain [102174] (1 protein)
  12. 688681c.2.1.13: Ornithine cyclodeaminase-like [110436] (2 protein domains)
    Pfam PF02423; contains additional alpha+beta dimerisation subdomain mostly formed by the N-terminal meander beta-sheet

More info for Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains

Timeline for Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains: