SCOPe 2.08: Domain d1xkta1: 1xkt A:2218-2502

Lineage for d1xkta1 (1xkt A:2218-2502)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.69: alpha/beta-Hydrolases [53473] (1 superfamily)
   core: 3 layers, a/b/a; mixed beta-sheet of 8 strands, order 12435678, strand 2 is antiparallel to the rest

4. Superfamily c.69.1: alpha/beta-Hydrolases [53474] (43 families)
   many members have left-handed crossover connection between strand 8 and additional strand 9

5. Family c.69.1.22: Thioesterase domain of polypeptide, polyketide and fatty acid synthases [69584] (4 proteins)
   Pfam PF00975

6. Protein Fatty acid synthase [117709] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [117710] (1 PDB entry)
   Uniprot P49327 2212-2496

8. Domain d1xkta1: 1xkt A:2218-2502 [115423]
   Other proteins in same PDB: d1xkta2, d1xktb2

Details for d1xkta1

PDB Entry: 1xkt, 2.6 Å

PDB Description: Human fatty acid synthase: Structure and substrate selectivity of the thioesterase domain

PDB Compounds: (A:) fatty acid synthase

SCOPe Domain Sequences for d1xkta1:

Sequence, based on SEQRES records:

>d1xkta1 c.69.1.22 (A:2218-2502) Fatty acid synthase {Human (Homo sapiens) [TaxId: 9606]}
nlrsllvnpegptlmrlnsvqsserplflvhpiegsttvfhslasrlsiptyglqctraa
pldsihslaayyidcirqvqpegpyrvagysygacvafemcsqlqaqqspapthnslflf
dgsptyvlaytqsyrakltpgceaeaeteaicffvqqftdmehnrvleallplkgleerv
aaavdliikshqgldrqelsfaarsfyyklraaeqytpkakyygnvmllraktggayged
lgadynlsqvcdgkvsvhviegdhrtllegsglesiisiihssla

Sequence, based on observed residues (ATOM records):

>d1xkta1 c.69.1.22 (A:2218-2502) Fatty acid synthase {Human (Homo sapiens) [TaxId: 9606]}
nlrsllvnpegptlmrlnsvqsserplflvhpiegsttvfhslasrlsiptyglqctraa
pldsihslaayyidcirqvqpegpyrvagysygacvafemcsqlqaqhnslflfdgspty
pgceaeaeteaicffvqqftdmehnrvleallplkgleervaaavdliikshqgldrqel
sfaarsfyyklraaeqytpkakyygnvmllraktglgadynlsqvcdgkvsvhviegdhr
tllesglesiisiihssla

Timeline for d1xkta1:

• d1xkta1 first appeared in SCOP 1.71, called d1xkta_
  
• d1xkta1 appears in SCOPe 2.07