SCOPe 2.08: Domain d1tq0.2: 1tq0 C:,D:

Lineage for d1tq0.2 (1tq0 C:,D:)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (49 proteins)

6. Protein Thrombin [50531] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50532] (171 PDB entries)
   Uniprot P00734 331-361,364-421 ! Uniprot P00734 334-360 364-510 518-619 ! Uniprot P00734 328-620 ! Uniprot P00734 355-621 ! Uniprot P00734 328-620

8. Domain d1tq0.2: 1tq0 C:,D: [107197]
   mutant

Details for d1tq0.2

PDB Entry: 1tq0, 2.8 Å

PDB Description: crystal structure of the potent anticoagulant thrombin mutant w215a/e217a in free form

PDB Compounds: (C:) Prothrombin, (D:) Prothrombin

SCOPe Domain Sequences for d1tq0.2:

Sequence, based on SEQRES records:

>g1tq0.2 b.47.1.2 (C:,D:) Thrombin {Human (Homo sapiens) [TaxId: 9606]}
adcglrplfekksledkterellesyidXivegsdaeigmspwqvmlfrkspqellcgas
lisdrwvltaahcllyppwdknftendllvrigkhsrtryerniekismlekiyihpryn
wrenldrdialmklkkpvafsdyihpvclpdretaasllqagykgrvtgwgnlketwtan
vgkgqpsvlqvvnlpiverpvckdstriritdnmfcagykpdegkrgdacegdsggpfvm
kspfnnrwyqmgivsagagcdrdgkygfythvfrlkkwiqkvidqf

Sequence, based on observed residues (ATOM records):

>g1tq0.2 b.47.1.2 (C:,D:) Thrombin {Human (Homo sapiens) [TaxId: 9606]}
adcglrplfekksledkterellesyidXivegsdaeigmspwqvmlfrkspqellcgas
lisdrwvltaahcllyppwdknftendllvrigkhsrtryerniekismlekiyihpryn
wrenldrdialmklkkpvafsdyihpvclpdretaasllqagykgrvtgwgnlkegqpsv
lqvvnlpiverpvckdstriritdnmfcagykpkrgdacegdsggpfvmkspfnnrwyqm
givsagagcdrdgkygfythvfrlkkwiqkvidqf

Timeline for d1tq0.2:

• d1tq0.2 first appeared in SCOP 1.69
  
• d1tq0.2 appears in SCOPe 2.07