SCOP 1.73: Domain d1szda_: 1szd A:

Lineage for d1szda_ (1szd A:)

1. Root: SCOP 1.73

2. Class c: Alpha and beta proteins (a/b) [51349] (141 folds)

3. Fold c.31: DHS-like NAD/FAD-binding domain [52466] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like

4. Superfamily c.31.1: DHS-like NAD/FAD-binding domain [52467] (6 families)
   binds cofactor molecules in the opposite direction than classical Rossmann fold

5. Family c.31.1.5: Sir2 family of transcriptional regulators [63984] (7 proteins)
   silent information regulator 2; contains insertion of a rubredoxin-like zinc finger domain

6. Protein Hst2 [102294] (1 species)

7. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [102295] (5 PDB entries)

8. Domain d1szda_: 1szd A: [106150]
   complexed with apr, cl, gol, zn

Details for d1szda_

PDB Entry: 1szd, 1.5 Å

PDB Description: Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD+-dependent Sir2 histone/protein deacetylases

PDB Compounds: (A:) NAD-dependent deacetylase HST2

SCOP Domain Sequences for d1szda_:

Sequence, based on SEQRES records:

>d1szda_ c.31.1.5 (A:) Hst2 {Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]}
masmsvstastemsvrkiaahmksnpnakvifmvgagistscgipdfrspgtglyhnlar
lklpypeavfdvdffqsdplpfytlakelypgnfrpskfhyllklfqdkdvlkrvytqni
dtlerqagvkddliieahgsfahchcigcgkvyppqvfksklaehpikdfvkcdvcgelv
kpaivffgedlpdsfsetwlndsewlrekittsgkhpqqplvivvgtslavypfaslpee
iprkvkrvlcnletvgdfkankrptdlivhqysdefaeqlveelgwqedfekilta

Sequence, based on observed residues (ATOM records):

>d1szda_ c.31.1.5 (A:) Hst2 {Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]}
masmsvstastemsvrkiaahmksnpnakvifmvgagistscgipdfrspgtglyhnlar
lklpypeavfdvdffqsdplpfytlakelypgnfrpskfhyllklfqdkdvlkrvytqni
dtlerqagvkddliieahgsfahchcigcgkvyppqvfksklaehpikdfvkcdvcgelv
kpaivffgedlpdsfsetwlndsewlrekittqqplvivvgtslavypfaslpeeiprkv
krvlcnletvgdfkankrptdlivhqysdefaeqlveelgwqedfekilta

Timeline for d1szda_:

• d1szda_ first appeared in SCOP 1.69
  
• d1szda_ appears in SCOP 1.71
  
• d1szda_ appears in SCOP 1.75
  
• d1szda_ appears in the current release, SCOPe 2.08, called d1szda1