PDB entry 1szd

View 1szd on RCSB PDB site
Description: Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD+-dependent Sir2 histone/protein deacetylases
Class: gene regulation
Keywords: hst2, Sir2, Sirtuin, histone deacetylase, protein deacetylase
Deposited on 2004-04-05, released 2004-06-15
The last revision prior to the SCOP 1.73 freeze date was dated 2004-06-15, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 1.5 Å
R-factor: 0.214
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: NAD-dependent deacetylase HST2
    Species: Saccharomyces cerevisiae
    Database cross-references and differences (RAF-indexed):
    • Uniprot P53686 (3-End)
      • his tag (0-2)
    Domains in SCOP 1.73: d1szda_
  • Chain 'B':
    Compound: Histone H4 peptide
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • Uniprot P02309 (0-End)
      • modified residue (4)
  • Heterogens: CL, ZN, APR, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1szdA (A:)
masmsvstastemsvrkiaahmksnpnakvifmvgagistscgipdfrspgtglyhnlar
lklpypeavfdvdffqsdplpfytlakelypgnfrpskfhyllklfqdkdvlkrvytqni
dtlerqagvkddliieahgsfahchcigcgkvyppqvfksklaehpikdfvkcdvcgelv
kpaivffgedlpdsfsetwlndsewlrekittsgkhpqqplvivvgtslavypfaslpee
iprkvkrvlcnletvgdfkankrptdlivhqysdefaeqlveelgwqedfekiltaq

    Sequence, based on observed residues (ATOM records): (download) 
    >1szdA (A:)
masmsvstastemsvrkiaahmksnpnakvifmvgagistscgipdfrspgtglyhnlar
lklpypeavfdvdffqsdplpfytlakelypgnfrpskfhyllklfqdkdvlkrvytqni
dtlerqagvkddliieahgsfahchcigcgkvyppqvfksklaehpikdfvkcdvcgelv
kpaivffgedlpdsfsetwlndsewlrekittqqplvivvgtslavypfaslpeeiprkv
krvlcnletvgdfkankrptdlivhqysdefaeqlveelgwqedfekilta

  • Chain 'B':
    No sequence available.