Lineage for Family c.31.1.5: Sir2 family of transcriptional regulators
- Root: SCOP 1.73
Class c: Alpha and beta proteins (a/b) [51349] (141 folds) 
Fold c.31: DHS-like NAD/FAD-binding domain [52466] (1 superfamily)
3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-likeSuperfamily c.31.1: DHS-like NAD/FAD-binding domain [52467] (6 families) 
binds cofactor molecules in the opposite direction than classical Rossmann fold
Family c.31.1.5: Sir2 family of transcriptional regulators [63984] (7 proteins)
silent information regulator 2; contains insertion of a rubredoxin-like zinc finger domain
Proteins:
AF0112, Sir2 homolog (Sir2-AF2) [82380] (1 species) Species Archaeon Archaeoglobus fulgidus [TaxId:2234] [82381] (3 PDB entries)
AF1676, Sir2 homolog (Sir2-AF1?) [63985] (1 species) Species Archaeon Archaeoglobus fulgidus [TaxId:2234] [63986] (6 PDB entries)
Hst2 [102294] (1 species) Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [102295] (5 PDB entries)
NAD-dependent deacetylase CobB [102292] (1 species) Species Escherichia coli [TaxId:562] [102293] (1 PDB entry)
NAD-dependent deacetylase NpdA [142126] (1 species) Species Thermotoga maritima [TaxId:2336] [142127] (8 PDB entries)
NAD-dependent deacetylase sirtuin-5 [142128] (1 species) Species Human (Homo sapiens) [TaxId:9606] [142129] (2 PDB entries)
Sirt2 histone deacetylase [63987] (1 species) Species Human (Homo sapiens) [TaxId:9606] [63988] (1 PDB entry)
More info for Family c.31.1.5: Sir2 family of transcriptional regulators
Timeline for Family c.31.1.5: Sir2 family of transcriptional regulators:
- Family c.31.1.5: Sir2 family of transcriptional regulators first appeared in SCOP 1.57
- Family c.31.1.5: Sir2 family of transcriptional regulators appears in SCOP 1.71
- Family c.31.1.5: Sir2 family of transcriptional regulators appears in SCOP 1.75
- Family c.31.1.5: Sir2 family of transcriptional regulators appears in the current release, SCOPe 2.08