Lineage for d4li5a_ (4li5 A:)

  1. Root: SCOPe 2.05
  2. 1886641Class d: Alpha and beta proteins (a+b) [53931] (381 folds)
  3. 1929110Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 1929111Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 1929232Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 1930282Protein EGF receptor tyrosine kinase, Erbb-1 [82795] (1 species)
    PTK group; EGFR subfamily; membrane spanning protein tyrosine kinase
  7. 1930283Species Human (Homo sapiens) [TaxId:9606] [82796] (65 PDB entries)
    Uniprot P00533 702-1018
  8. 1930301Domain d4li5a_: 4li5 A: [224685]
    automated match to d2eb2a_
    complexed with 1wy, na

Details for d4li5a_

PDB Entry: 4li5 (more details), 2.64 Å

PDB Description: egfr-k in complex with n-[3-[[5-chloro-4-(1h-indol-3-yl)pyrimidin-2-yl]amino]-4-methoxy-phenyl] prop-2-enamide
PDB Compounds: (A:) Epidermal growth factor receptor

SCOPe Domain Sequences for d4li5a_:

Sequence, based on SEQRES records: (download)

>d4li5a_ d.144.1.7 (A:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
gsmgeapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreats
pkankeildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsq
yllnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhae
ggkvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekger
lpqppictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsp
tdsnfyralmdeedmddvvdadeylipq

Sequence, based on observed residues (ATOM records): (download)

>d4li5a_ d.144.1.7 (A:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
gsmgeapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreats
pkankeildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsq
yllnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhae
ggkvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekger
lpqppictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdeddvvdad
eylipq

SCOPe Domain Coordinates for d4li5a_:

Click to download the PDB-style file with coordinates for d4li5a_.
(The format of our PDB-style files is described here.)

Timeline for d4li5a_: