PDB entry 4re6

View 4re6 on RCSB PDB site
Description: Acylaminoacyl peptidase complexed with a chloromethylketone inhibitor
Class: hydrolase/hydrolase inhibitor
Keywords: beta-propeller, alpha-beta-hydrolase fold, chloromethyl-ketone inhibitor, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2014-09-22, released 2015-01-28
The last revision prior to the SCOPe 2.05 freeze date was dated 2015-01-28, with a file datestamp of 2015-01-23.
Experiment type: XRAY
Resolution: 2.55 Å
R-factor: 0.214
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Acylamino-acid-releasing enzyme
    Species: Aeropyrum pernix [TaxId:272557]
    Gene: APE_1547.1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4re6a1, d4re6a2
  • Chain 'B':
    Compound: Acylamino-acid-releasing enzyme
    Species: Aeropyrum pernix [TaxId:272557]
    Gene: APE_1547.1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4re6b1, d4re6b2
  • Chain 'C':
    Compound: Acylamino-acid-releasing enzyme
    Species: Aeropyrum pernix [TaxId:272557]
    Gene: APE_1547.1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4re6c1, d4re6c2
  • Chain 'D':
    Compound: Acylamino-acid-releasing enzyme
    Species: Aeropyrum pernix [TaxId:272557]
    Gene: APE_1547.1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4re6d1, d4re6d2
  • Heterogens: Y3A, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4re6A (A:)
mriimpvefsrivrdverliavekyslqgvvdgdkllvvgfsegsvnaylydggetvkln
repinsvldphygvgrvilvrdvskgaeqhalfkvntsrpgeeqrleavkpmrilsgvdt
geavvftgatedrvalyaldggglrelarlpgfgfvsdirgdliaglgffgggrvslfts
nlssgglrvfdsgegsfssasispgmkvtagletarearlvtvdprdgsvedlelpskdf
ssyrptaitwlgylpdgrlavvarregrsavfidgerveapqgnhgrvvlwrgklvtsht
slstpprivslpsgepllegglpedlrrsiagsrlvwvesfdgsrvptyvlesgraptpg
ptvvlvhggpfaedsdswdtfaaslaaagfhvvmpnyrgstgygeewrlkiigdpcggel
edvsaaarwaresglaselyimgysyggymtlcaltmkpglfkagvagasvvdweemyel
sdaafrnfieqltggsreimrsrspinhvdrikeplalihpqndsrtplkpllrlmgell
argktfeahiipdaghaintmedavkillpavfflatqrerr

    Sequence, based on observed residues (ATOM records): (download) 
    >4re6A (A:)
mpvefsrivrdverliavekyslqgvvdgdkllvvgfsegsvnaylydggetvklnrepi
nsvldphygvgrvilvrdvskgaeqhalfkvntsrpgeeqrleavkpmrilsgvdtgeav
vftgatedrvalyaldggglrelarlpgfgfvsdirgdliaglgffgggrvslftsnlss
gglrvfdsgegsfssasispgmkvtagletarearlvtvdprdgsvedlelpskdfssyr
ptaitwlgylpdgrlavvarregrsavfidgerveapqgnhgrvvlwrgklvtshtslst
pprivslpsgepllegglpedlrrsiagsrlvwvesfdgsrvptyvlesgraptpgptvv
lvhggpfaedsdswdtfaaslaaagfhvvmpnyrgstgygeewrlkiigdpcggeledvs
aaarwaresglaselyimgysyggymtlcaltmkpglfkagvagasvvdweemyelsdaa
frnfieqltggsreimrsrspinhvdrikeplalihpqndsrtplkpllrlmgellargk
tfeahiipdaghaintmedavkillpavfflatqrer

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4re6B (B:)
mriimpvefsrivrdverliavekyslqgvvdgdkllvvgfsegsvnaylydggetvkln
repinsvldphygvgrvilvrdvskgaeqhalfkvntsrpgeeqrleavkpmrilsgvdt
geavvftgatedrvalyaldggglrelarlpgfgfvsdirgdliaglgffgggrvslfts
nlssgglrvfdsgegsfssasispgmkvtagletarearlvtvdprdgsvedlelpskdf
ssyrptaitwlgylpdgrlavvarregrsavfidgerveapqgnhgrvvlwrgklvtsht
slstpprivslpsgepllegglpedlrrsiagsrlvwvesfdgsrvptyvlesgraptpg
ptvvlvhggpfaedsdswdtfaaslaaagfhvvmpnyrgstgygeewrlkiigdpcggel
edvsaaarwaresglaselyimgysyggymtlcaltmkpglfkagvagasvvdweemyel
sdaafrnfieqltggsreimrsrspinhvdrikeplalihpqndsrtplkpllrlmgell
argktfeahiipdaghaintmedavkillpavfflatqrerr

    Sequence, based on observed residues (ATOM records): (download) 
    >4re6B (B:)
pvefsrivrdverliavekyslqgvvdgdkllvvgfsegsvnaylydggetvklnrepin
svldphygvgrvilvrdvskgaeqhalfkvntsrpgeeqrleavkpmrilsgvdtgeavv
ftgatedrvalyaldggglrelarlpgfgfvsdirgdliaglgffgggrvslftsnlssg
glrvfdsgegsfssasispgmkvtagletarearlvtvdprdgsvedlelpskdfssyrp
taitwlgylpdgrlavvarregrsavfidgerveapqgnhgrvvlwrgklvtshtslstp
privslpsgepllegglpedlrrsiagsrlvwvesfdgsrvptyvlesgraptpgptvvl
vhggpfaedsdswdtfaaslaaagfhvvmpnyrgstgygeewrlkiigdpcggeledvsa
aarwaresglaselyimgysyggymtlcaltmkpglfkagvagasvvdweemyelsaafr
nfieqltggsreimrsrspinhvdrikeplalihpqndsrtplkpllrlmgellargktf
eahiipdaghaintmedavkillpavfflatqre

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4re6C (C:)
mriimpvefsrivrdverliavekyslqgvvdgdkllvvgfsegsvnaylydggetvkln
repinsvldphygvgrvilvrdvskgaeqhalfkvntsrpgeeqrleavkpmrilsgvdt
geavvftgatedrvalyaldggglrelarlpgfgfvsdirgdliaglgffgggrvslfts
nlssgglrvfdsgegsfssasispgmkvtagletarearlvtvdprdgsvedlelpskdf
ssyrptaitwlgylpdgrlavvarregrsavfidgerveapqgnhgrvvlwrgklvtsht
slstpprivslpsgepllegglpedlrrsiagsrlvwvesfdgsrvptyvlesgraptpg
ptvvlvhggpfaedsdswdtfaaslaaagfhvvmpnyrgstgygeewrlkiigdpcggel
edvsaaarwaresglaselyimgysyggymtlcaltmkpglfkagvagasvvdweemyel
sdaafrnfieqltggsreimrsrspinhvdrikeplalihpqndsrtplkpllrlmgell
argktfeahiipdaghaintmedavkillpavfflatqrerr

    Sequence, based on observed residues (ATOM records): (download) 
    >4re6C (C:)
mpvefsrivrdverliavekyslqgvvdgdkllvvgfsegsvnaylydggetvklnrepi
nsvldphygvgrvilvrdvskgaeqhalfkvntsrpgeeqrleavkpmrilsgvdtgeav
vftgatedrvalyaldggglrelarlpgfgfvsdirgdliaglgffgggrvslftsnlss
gglrvfdsgegsfssasispgmkvtagletarearlvtvdprdgsvedlelpskdfssyr
ptaitwlgylpdgrlavvarregrsavfidgerveapqgnhgrvvlwrgklvtshtslst
pprivslpsgepllegglpedlrrsiagsrlvwvesfdgsrvptyvlesgraptpgptvv
lvhggpfaedsdswdtfaaslaaagfhvvmpnyrgstgygeewrlkiigdpcggeledvs
aaarwaresglaselyimgysyggymtlcaltmkpglfkagvagasvvdweemyelsdaa
frnfieqltggsreimrsrspinhvdrikeplalihpqndsrtplkpllrlmgellargk
tfeahiipdaghaintmedavkillpavfflatqrer

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4re6D (D:)
mriimpvefsrivrdverliavekyslqgvvdgdkllvvgfsegsvnaylydggetvkln
repinsvldphygvgrvilvrdvskgaeqhalfkvntsrpgeeqrleavkpmrilsgvdt
geavvftgatedrvalyaldggglrelarlpgfgfvsdirgdliaglgffgggrvslfts
nlssgglrvfdsgegsfssasispgmkvtagletarearlvtvdprdgsvedlelpskdf
ssyrptaitwlgylpdgrlavvarregrsavfidgerveapqgnhgrvvlwrgklvtsht
slstpprivslpsgepllegglpedlrrsiagsrlvwvesfdgsrvptyvlesgraptpg
ptvvlvhggpfaedsdswdtfaaslaaagfhvvmpnyrgstgygeewrlkiigdpcggel
edvsaaarwaresglaselyimgysyggymtlcaltmkpglfkagvagasvvdweemyel
sdaafrnfieqltggsreimrsrspinhvdrikeplalihpqndsrtplkpllrlmgell
argktfeahiipdaghaintmedavkillpavfflatqrerr

    Sequence, based on observed residues (ATOM records): (download) 
    >4re6D (D:)
mpvefsrivrdverliavekyslqgvvdgdkllvvgfsegsvnaylydggetvklnrepi
nsvldphygvgrvilvrdvskgaeqhalfkvntsrpgeeqrleavkpmrilsgvdtgeav
vftgatedrvalyaldggglrelarlpgfgfvsdirgdliaglgffgggrvslftsnlss
gglrvfdsgegsfssasispgmkvtagletarearlvtvdprdgsvedlelpskdfssyr
ptaitwlgylpdgrlavvarregrsavfidgerveapqgnhgrvvlwrgklvtshtslst
pprivslpsgepllegglpedlrrsiagsrlvwvesfdgsrvptyvlesgraptpgptvv
lvhggpfaedsdswdtfaaslaaagfhvvmpnyrgstgygeewrlkiigdpcggeledvs
aaarwaresglaselyimgysyggymtlcaltmkpglfkagvagasvvdweemyelsdaa
frnfieqltggsreimrsrspinhvdrikeplalihpqndsrtplkpllrlmgellargk
tfeahiipdaghaintmedavkillpavfflatqrer