PDB entry 4kv5

View 4kv5 on RCSB PDB site
Description: scFv GC1009 in complex with TGF-beta1.
Class: immune system
Keywords: Cysteine knot, Fab, TGF-beta receptor mimetic, TGF-beta, TGF-beta receptor, immune system
Deposited on 2013-05-22, released 2014-09-24
The last revision prior to the SCOPe 2.07 freeze date was dated 2014-12-03, with a file datestamp of 2014-11-28.
Experiment type: XRAY
Resolution: 3 Å
R-factor: 0.233
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Transforming growth factor beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: TGFB1, TGFB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4kv5a_
  • Chain 'B':
    Compound: Transforming growth factor beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: TGFB1, TGFB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4kv5b_
  • Chain 'C':
    Compound: Transforming growth factor beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: TGFB1, TGFB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4kv5c_
  • Chain 'D':
    Compound: Transforming growth factor beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: TGFB1, TGFB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4kv5d_
  • Chain 'E':
    Compound: heavy chain GC1009 scFv
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4KV5 (0-End)
    Domains in SCOPe 2.07: d4kv5e_
  • Chain 'F':
    Compound: light chain GC1009 scFv
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4KV5 (0-End)
    Domains in SCOPe 2.07: d4kv5f1, d4kv5f2
  • Chain 'G':
    Compound: heavy chain GC1009 scFv
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4KV5
    Domains in SCOPe 2.07: d4kv5g_
  • Chain 'H':
    Compound: heavy chain GC1009 scFv
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4KV5 (0-End)
    Domains in SCOPe 2.07: d4kv5h_
  • Chain 'I':
    Compound: light chain GC1009 scFv
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4KV5 (0-End)
    Domains in SCOPe 2.07: d4kv5i1, d4kv5i2
  • Chain 'J':
    Compound: heavy chain GC1009 scFv
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4KV5 (0-End)
    Domains in SCOPe 2.07: d4kv5j_
  • Chain 'K':
    Compound: light chain GC1009 scFv
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4KV5 (0-End)
    Domains in SCOPe 2.07: d4kv5k1, d4kv5k2
  • Chain 'L':
    Compound: light chain GC1009 scFv
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4KV5
    Domains in SCOPe 2.07: d4kv5l1, d4kv5l2

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4kv5A (A:)
aldtnycfssteknccvrqlyidfrkdlgwkwihepkgyhanfclgpcpyiwsldtqysk
vlalynqhnpgasaapccvpqaleplpivyyvgrkpkveqlsnmivrsckcs

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4kv5B (B:)
aldtnycfssteknccvrqlyidfrkdlgwkwihepkgyhanfclgpcpyiwsldtqysk
vlalynqhnpgasaapccvpqaleplpivyyvgrkpkveqlsnmivrsckcs

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4kv5C (C:)
aldtnycfssteknccvrqlyidfrkdlgwkwihepkgyhanfclgpcpyiwsldtqysk
vlalynqhnpgasaapccvpqaleplpivyyvgrkpkveqlsnmivrsckcs

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4kv5D (D:)
aldtnycfssteknccvrqlyidfrkdlgwkwihepkgyhanfclgpcpyiwsldtqysk
vlalynqhnpgasaapccvpqaleplpivyyvgrkpkveqlsnmivrsckcs

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4kv5E (E:)
qvqlvqsgaevkkpgssvkvsckasgytfssnviswvrqapgqglewmggvipivdiany
aqrfkgrvtitadeststtymelsslrsedtavyycastlglvldamdywgqgtlvtvss
ggggsggggsggggsa

    Sequence, based on observed residues (ATOM records): (download) 
    >4kv5E (E:)
qvqlvqsgaevkkpgssvkvsckasgytfssnviswvrqapgqglewmggvipivdiany
aqrfkgrvtitadeststtymelsslrsedtavyycastlglvldamdywgqgtlvtvss

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >4kv5F (F:)
letvltqspgtlslspgeratlscrasqslgssylawyqqkpgqaprlliygassrapgi
pdrfsgsgsgtdftltisrlepedfavyycqqyadspitfgqgtrleikrhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4kv5F (F:)
letvltqspgtlslspgeratlscrasqslgssylawyqqkpgqaprlliygassrapgi
pdrfsgsgsgtdftltisrlepedfavyycqqyadspitfgqgtrleikr

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >4kv5G (G:)
qvqlvqsgaevkkpgssvkvsckasgytfssnviswvrqapgqglewmggvipivdiany
aqrfkgrvtitadeststtymelsslrsedtavyycastlglvldamdywgqgtlvtvss
ggggsggggsggggsa

    Sequence, based on observed residues (ATOM records): (download) 
    >4kv5G (G:)
vqlvqsgaevkkpgssvkvsckasgytfssnviswvrqapgqglewmggvipivdianya
qrfkgrvtitadeststtymelsslrsedtavyycastlglvldamdywgqgtlvtvss

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >4kv5H (H:)
qvqlvqsgaevkkpgssvkvsckasgytfssnviswvrqapgqglewmggvipivdiany
aqrfkgrvtitadeststtymelsslrsedtavyycastlglvldamdywgqgtlvtvss
ggggsggggsggggsa

    Sequence, based on observed residues (ATOM records): (download) 
    >4kv5H (H:)
qvqlvqsgaevkkpgssvkvsckasgytfssnviswvrqapgqglewmggvipivdiany
aqrfkgrvtitadeststtymelsslrsedtavyycastlglvldamdywgqgtlvtvss

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >4kv5I (I:)
letvltqspgtlslspgeratlscrasqslgssylawyqqkpgqaprlliygassrapgi
pdrfsgsgsgtdftltisrlepedfavyycqqyadspitfgqgtrleikrhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4kv5I (I:)
letvltqspgtlslspgeratlscrasqslgssylawyqqkpgqaprlliygassrapgi
pdrfsgsgsgtdftltisrlepedfavyycqqyadspitfgqgtrleikr

  • Chain 'J':
    Sequence, based on SEQRES records: (download) 
    >4kv5J (J:)
qvqlvqsgaevkkpgssvkvsckasgytfssnviswvrqapgqglewmggvipivdiany
aqrfkgrvtitadeststtymelsslrsedtavyycastlglvldamdywgqgtlvtvss
ggggsggggsggggsa

    Sequence, based on observed residues (ATOM records): (download) 
    >4kv5J (J:)
qvqlvqsgaevkkpgssvkvsckasgytfssnviswvrqapgqglewmggvipivdiany
aqrfkgrvtitadeststtymelsslrsedtavyycastlglvldamdywgqgtlvtvss

  • Chain 'K':
    Sequence, based on SEQRES records: (download) 
    >4kv5K (K:)
letvltqspgtlslspgeratlscrasqslgssylawyqqkpgqaprlliygassrapgi
pdrfsgsgsgtdftltisrlepedfavyycqqyadspitfgqgtrleikrhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4kv5K (K:)
letvltqspgtlslspgeratlscrasqslgssylawyqqkpgqaprlliygassrapgi
pdrfsgsgsgtdftltisrlepedfavyycqqyadspitfgqgtrleikr

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >4kv5L (L:)
letvltqspgtlslspgeratlscrasqslgssylawyqqkpgqaprlliygassrapgi
pdrfsgsgsgtdftltisrlepedfavyycqqyadspitfgqgtrleikrhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4kv5L (L:)
etvltqspgtlslspgeratlscrasqslgssylawyqqkpgqaprlliygassrapgip
drfsgsgsgtdftltisrlepedfavyycqqyadspitfgqgtrleikr