PDB entry 4k8v

View 4k8v on RCSB PDB site
Description: Structure of cyclic GMP-AMP Synthase (cGAS)
Class: transferase
Keywords: nucleotidyltransferase, DNA, TRANSFERASE
Deposited on 2013-04-18, released 2013-05-15
The last revision prior to the SCOPe 2.04 freeze date was dated 2013-08-28, with a file datestamp of 2013-08-23.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.177
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cyclic GMP-AMP synthase
    Species: Mus musculus [TaxId:10090]
    Gene: Mb21d1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8C6L5 (1-361)
      • expression tag (0)
    Domains in SCOPe 2.04: d4k8va1, d4k8va2
  • Chain 'B':
    Compound: Cyclic GMP-AMP synthase
    Species: Mus musculus [TaxId:10090]
    Gene: Mb21d1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8C6L5 (1-361)
      • expression tag (0)
    Domains in SCOPe 2.04: d4k8vb1, d4k8vb2
  • Chain 'C':
    Compound: Cyclic GMP-AMP synthase
    Species: Mus musculus [TaxId:10090]
    Gene: Mb21d1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8C6L5 (1-361)
      • expression tag (0)
    Domains in SCOPe 2.04: d4k8vc1, d4k8vc2
  • Chain 'D':
    Compound: Cyclic GMP-AMP synthase
    Species: Mus musculus [TaxId:10090]
    Gene: Mb21d1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8C6L5 (1-361)
      • expression tag (0)
    Domains in SCOPe 2.04: d4k8vd1, d4k8vd2
  • Heterogens: ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4k8vA (A:)
spdklkkvldklrlkrkdiseaaetvnkvverllrrmqkresefkgveqlntgsyyehvk
isapnefdvmfklevprielqeyyetgafylvkfkriprgnplshflegevlsatkmlsk
frkiikeevkeikdidvsvekekpgspavtllirnpeeisvdiilaleskgswpistkeg
lpiqgwlgtkvrtnlrrepfylvpknakdgnsfqgetwrlsfshtekyilnnhgiektcc
essgakccrkeclklmkylleqlkkefqeldafcsyhvktaifhmwtqdpqdsqwdprnl
sscfdkllaffleclrtekldhyfipkfnlfsqelidrkskeflskkieyernngfpifd
kl

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4k8vB (B:)
spdklkkvldklrlkrkdiseaaetvnkvverllrrmqkresefkgveqlntgsyyehvk
isapnefdvmfklevprielqeyyetgafylvkfkriprgnplshflegevlsatkmlsk
frkiikeevkeikdidvsvekekpgspavtllirnpeeisvdiilaleskgswpistkeg
lpiqgwlgtkvrtnlrrepfylvpknakdgnsfqgetwrlsfshtekyilnnhgiektcc
essgakccrkeclklmkylleqlkkefqeldafcsyhvktaifhmwtqdpqdsqwdprnl
sscfdkllaffleclrtekldhyfipkfnlfsqelidrkskeflskkieyernngfpifd
kl

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4k8vC (C:)
spdklkkvldklrlkrkdiseaaetvnkvverllrrmqkresefkgveqlntgsyyehvk
isapnefdvmfklevprielqeyyetgafylvkfkriprgnplshflegevlsatkmlsk
frkiikeevkeikdidvsvekekpgspavtllirnpeeisvdiilaleskgswpistkeg
lpiqgwlgtkvrtnlrrepfylvpknakdgnsfqgetwrlsfshtekyilnnhgiektcc
essgakccrkeclklmkylleqlkkefqeldafcsyhvktaifhmwtqdpqdsqwdprnl
sscfdkllaffleclrtekldhyfipkfnlfsqelidrkskeflskkieyernngfpifd
kl

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4k8vD (D:)
spdklkkvldklrlkrkdiseaaetvnkvverllrrmqkresefkgveqlntgsyyehvk
isapnefdvmfklevprielqeyyetgafylvkfkriprgnplshflegevlsatkmlsk
frkiikeevkeikdidvsvekekpgspavtllirnpeeisvdiilaleskgswpistkeg
lpiqgwlgtkvrtnlrrepfylvpknakdgnsfqgetwrlsfshtekyilnnhgiektcc
essgakccrkeclklmkylleqlkkefqeldafcsyhvktaifhmwtqdpqdsqwdprnl
sscfdkllaffleclrtekldhyfipkfnlfsqelidrkskeflskkieyernngfpifd
kl