PDB entry 3twr

View 3twr on RCSB PDB site
Description: Crystal structure of ARC4 from human Tankyrase 2 in complex with peptide from human 3BP2
Class: signaling protein/peptide
Keywords: ankyrin repeat, protein-protein interaction, substrate recruitment, poly(ADP-ribosyl)ation, SIGNALING PROTEIN-PEPTIDE complex
Deposited on 2011-09-22, released 2011-12-07
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-12-28, with a file datestamp of 2011-12-23.
Experiment type: XRAY
Resolution: 1.55 Å
R-factor: 0.182
AEROSPACI score: 0.64 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: tankyrase-2
    Species: Homo sapiens [TaxId:9606]
    Gene: PARP5B, TANK2, TNKL, TNKS2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3twra_
  • Chain 'B':
    Compound: tankyrase-2
    Species: Homo sapiens [TaxId:9606]
    Gene: PARP5B, TANK2, TNKL, TNKS2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3twrb_
  • Chain 'C':
    Compound: tankyrase-2
    Species: Homo sapiens [TaxId:9606]
    Gene: PARP5B, TANK2, TNKL, TNKS2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3twrc_
  • Chain 'D':
    Compound: tankyrase-2
    Species: Homo sapiens [TaxId:9606]
    Gene: PARP5B, TANK2, TNKL, TNKS2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9H2K2 (3-End)
      • expression tag (2)
    Domains in SCOPe 2.07: d3twrd1, d3twrd2
  • Chain 'E':
    Compound: SH3 domain-binding protein 2
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: SH3 domain-binding protein 2
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: SH3 domain-binding protein 2
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: SH3 domain-binding protein 2
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: SO4, PE8, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3twrA (A:)
gamgnseadrqlleaakagdvetvkklctvqsvncrdiegrqstplhfaagynrvsvvey
llqhgadvhakdkgglvplhnacsyghyevaellvkhgavvnvadlwkftplheaaakgk
yeicklllqhgadptkknrdgntpldlvkdgdtdiqdllrgdaal

    Sequence, based on observed residues (ATOM records): (download) 
    >3twrA (A:)
seadrqlleaakagdvetvkklctvqsvncrdiegrqstplhfaagynrvsvveyllqhg
advhakdkgglvplhnacsyghyevaellvkhgavvnvadlwkftplheaaakgkyeick
lllqhgadptkknrdgntpldlvkdgdtdiqdllrgd

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3twrB (B:)
gamgnseadrqlleaakagdvetvkklctvqsvncrdiegrqstplhfaagynrvsvvey
llqhgadvhakdkgglvplhnacsyghyevaellvkhgavvnvadlwkftplheaaakgk
yeicklllqhgadptkknrdgntpldlvkdgdtdiqdllrgdaal

    Sequence, based on observed residues (ATOM records): (download) 
    >3twrB (B:)
gnseadrqlleaakagdvetvkklctvqsvncrdiegrqstplhfaagynrvsvveyllq
hgadvhakdkgglvplhnacsyghyevaellvkhgavvnvadlwkftplheaaakgkyei
cklllqhgadptkknrdgntpldlvkdgdtdiqdllr

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3twrC (C:)
gamgnseadrqlleaakagdvetvkklctvqsvncrdiegrqstplhfaagynrvsvvey
llqhgadvhakdkgglvplhnacsyghyevaellvkhgavvnvadlwkftplheaaakgk
yeicklllqhgadptkknrdgntpldlvkdgdtdiqdllrgdaal

    Sequence, based on observed residues (ATOM records): (download) 
    >3twrC (C:)
gnseadrqlleaakagdvetvkklctvqsvncrdiegrqstplhfaagynrvsvveyllq
hgadvhakdkgglvplhnacsyghyevaellvkhgavvnvadlwkftplheaaakgkyei
cklllqhgadptkknrdgntpldlvkdgdtdiqdllrg

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3twrD (D:)
gamgnseadrqlleaakagdvetvkklctvqsvncrdiegrqstplhfaagynrvsvvey
llqhgadvhakdkgglvplhnacsyghyevaellvkhgavvnvadlwkftplheaaakgk
yeicklllqhgadptkknrdgntpldlvkdgdtdiqdllrgdaal

    Sequence, based on observed residues (ATOM records): (download) 
    >3twrD (D:)
mgnseadrqlleaakagdvetvkklctvqsvncrdiegrqstplhfaagynrvsvveyll
qhgadvhakdkgglvplhnacsyghyevaellvkhgavvnvadlwkftplheaaakgkye
icklllqhgadptkknrdgntpldlvkdgdtdiqdllr

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    No sequence available.