PDB entry 3buv

View 3buv on RCSB PDB site
Description: Crystal structure of human Delta(4)-3-ketosteroid 5-beta-reductase in complex with NADP and HEPES. Resolution: 1.35 A.
Class: oxidoreductase
Keywords: 5-beta-reductase; catalytic tetrad; E120; HEPES; NADP, Bile acid catabolism, Disease mutation, Lipid metabolism, Oxidoreductase, Steroid metabolism
Deposited on 2008-01-03, released 2008-04-01
The last revision prior to the SCOPe 2.04 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 1.35 Å
R-factor: 0.218
AEROSPACI score: 0.68 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 3-oxo-5-beta-steroid 4-dehydrogenase
    Species: Homo sapiens [TaxId:9606]
    Gene: AKR1D1, SRD5B1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d3buva_
  • Chain 'B':
    Compound: 3-oxo-5-beta-steroid 4-dehydrogenase
    Species: Homo sapiens [TaxId:9606]
    Gene: AKR1D1, SRD5B1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d3buvb_
  • Heterogens: NAP, EPE, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3buvA (A:)
mdlsaashriplsdgnsipiiglgtysepkstpkgacatsvkvaidtgyrhidgayiyqn
ehevgeairekiaegkvrredifycgklwatnhvpemvrptlertlrvlqldyvdlyiie
vpmafkpgdeiyprdengkwlyhksnlcatweameackdaglvkslgvsnfnrrqlelil
nkpglkhkpvsnqvechpyftqpkllkfcqqhdivitaysplgtsrnpiwvnvssppllk
dallnslgkrynktaaqivlrfniqrgvvvipksfnlerikenfqifdfslteeemkdie
alnknvrfvellmwrdhpeypfhdey

    Sequence, based on observed residues (ATOM records): (download) 
    >3buvA (A:)
dlsaashriplsdgnsipiiglgtysepkstpkgacatsvkvaidtgyrhidgayiyqne
hevgeairekiaegkvrredifycgklwatnhvpemvrptlertlrvlqldyvdlyiiev
pmafkpgdeiyprdengkwlyhksnlcatweameackdaglvkslgvsnfnrrqleliln
kpglkhkpvsnqvechpyftqpkllkfcqqhdivitaysplgtsrnpiwvnvssppllkd
allnslgkrynktaaqivlrfniqrgvvvipksfnlerikenfqifdfslteeemkdiea
lnknvrfvellmwrdhpeypfhdey

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3buvB (B:)
mdlsaashriplsdgnsipiiglgtysepkstpkgacatsvkvaidtgyrhidgayiyqn
ehevgeairekiaegkvrredifycgklwatnhvpemvrptlertlrvlqldyvdlyiie
vpmafkpgdeiyprdengkwlyhksnlcatweameackdaglvkslgvsnfnrrqlelil
nkpglkhkpvsnqvechpyftqpkllkfcqqhdivitaysplgtsrnpiwvnvssppllk
dallnslgkrynktaaqivlrfniqrgvvvipksfnlerikenfqifdfslteeemkdie
alnknvrfvellmwrdhpeypfhdey

    Sequence, based on observed residues (ATOM records): (download) 
    >3buvB (B:)
dlsaashriplsdgnsipiiglgtysepkstpkgacatsvkvaidtgyrhidgayiyqne
hevgeairekiaegkvrredifycgklwatnhvpemvrptlertlrvlqldyvdlyiiev
pmafkpgdeiyprdengkwlyhksnlcatweameackdaglvkslgvsnfnrrqleliln
kpglkhkpvsnqvechpyftqpkllkfcqqhdivitaysplgtsrnpiwvnvssppllkd
allnslgkrynktaaqivlrfniqrgvvvipksfnlerikenfqifdfslteeemkdiea
lnknvrfvellmwrdhpeypfhdey