PDB entry 2aze

View 2aze on RCSB PDB site
Description: Structure of the Rb C-terminal domain bound to an E2F1-DP1 heterodimer
Class: cell cycle, transcription
Keywords: coiled coil, beta sandwich, CELL CYCLE, TRANSCRIPTION
Deposited on 2005-09-10, released 2006-01-31
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.55 Å
R-factor: 0.221
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Transcription factor Dp-1
    Species: Homo sapiens [TaxId:9606]
    Gene: TFDP1, DP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14186 (3-End)
      • cloning artifact (2)
    Domains in SCOPe 2.08: d2azea1, d2azea2
  • Chain 'B':
    Compound: Transcription factor E2F1
    Species: Homo sapiens [TaxId:9606]
    Gene: E2F1, RBBP3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2azeb1
  • Chain 'C':
    Compound: Retinoblastoma-associated protein
    Species: Homo sapiens [TaxId:9606]
    Gene: RB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2azec1
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2azeA (A:)
gefaqecqnleverqrrlerikqkqsqlqelilqqiafknlvqrnrhaeqqasrppppns
vihlpfiivntskktvidcsisndkfeylfnfdntfeihddievlkrmgmacglesgscs
aedlkmarslvpkalepyvtemaqgtvggvfitta

    Sequence, based on observed residues (ATOM records): (download) 
    >2azeA (A:)
faqecqnleverqrrlerikqkqsqlqelilqqiafknlvqrnrhaeqqasrppppnsvi
hlpfiivntskktvidcsisndkfeylfnfdntfeihddievlkrmgmacglesgscsae
dlkmarslvpkalepyvtemaqgtvggvf

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2azeB (B:)
gshmggrlegltqdlrqlqeseqqldhlmnicttqlrllsedtdsqrlayvtcqdlrsia
dpaeqmvmvikappetqlqavdssenfqislkskqgpidvflcpee

    Sequence, based on observed residues (ATOM records): (download) 
    >2azeB (B:)
grlegltqdlrqlqeseqqldhlmnicttqlrllsedtdsqrlayvtcqdlrsiadpaeq
mvmvikappetqlqavdssenfqislkskqgpidvflcpee

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2azeC (C:)
srilvsigesfgtsekfqkinqmvcnsdrvlkrsaegsnppkplkk

    Sequence, based on observed residues (ATOM records): (download) 
    >2azeC (C:)
srilvsigesfgtsekfqkinqmvcnsdrvlkrsaegsnppkpl