PDB entry 1zxv

View 1zxv on RCSB PDB site
Description: X-Ray Crystal Structure of the Anthrax Lethal Factor Bound to a Small Molecule Inhibitor, BI-MFM3, 3-{5-[5-(4-Chloro-phenyl)-furan-2-ylmethylene]-4-oxo-2-thioxo-thiazolidin-3-yl}-propionic acid.
Class: hydrolase
Keywords: Anthrax Toxin Lethal Factor, protein and small molecule inhibitor complex, zinc metalloproteinase, HYDROLASE
Deposited on 2005-06-08, released 2005-07-05
The last revision prior to the SCOPe 2.04 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.67 Å
R-factor: 0.231
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Lethal Factor
    Species: Bacillus anthracis [TaxId:1392]
    Gene: lef
    Database cross-references and differences (RAF-indexed):
    • GB AAA79216 (Start-775)
    Domains in SCOPe 2.04: d1zxva1, d1zxva2, d1zxva3
  • Chain 'B':
    Compound: Lethal Factor
    Species: Bacillus anthracis [TaxId:1392]
    Gene: lef
    Database cross-references and differences (RAF-indexed):
    • GB AAA79216 (Start-775)
    Domains in SCOPe 2.04: d1zxvb1, d1zxvb2, d1zxvb3
  • Heterogens: ZN, MFM

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1zxvA (A:)
agghgdvgmhvkekeknkdenkrkdeernktqeehlkeimkhivkievkgeeavkkeaae
kllekvpsdvlemykaiggkiyivdgditkhislealsedkkkikdiygkdallhehyvy
akegyepvlviqssedyventekalnvyyeigkilsrdilskinqpyqkfldvlntikna
sdsdgqdllftnqlkehptdfsvefleqnsnevqevfakafayyiepqhrdvlqlyapea
fnymdkfneqeinlsleelkdqrmlsryekwekikqhyqhwsdslseegrgllkklqipi
epkkddiihslsqeekellkriqidssdflsteekeflkklqidirdslseeekellnri
qvdssnplsekekeflkklkldiqpydinqrlqdtgglidspsinldvrkqykrdiqnid
allhqsigstlynkiylyenmninnltatlgadlvdstdntkinrgifnefkknfkysis
snymivdinerpaldnerlkwriqlspdtragylengklilqrnigleikdvqiikqsek
eyiridakvvpkskidtkiqeaqlninqewnkalglpkytklitfnvhnryasnivesay
lilnewknniqsdlikkvtnylvdgngrfvftditlpniaeqythqdeiyeqvhskglyv
pesrsillhgpskgvelrndsegfihefghavddyagylldknqsdlvtnskkfidifke
egsnltsygrtneaeffaeafrlmhstdhaerlkvqknapktfqfindqikfiins

    Sequence, based on observed residues (ATOM records): (download) 
    >1zxvA (A:)
ernktqeehlkeimkhivkievkgeeavkkeaaekllekvpsdvlemykaiggkiyivdg
ditkhislealsedkkkikdiygkdallhehyvyakegyepvlviqssedyventekaln
vyyeigkilsrdilskinqpyqkfldvlntiknasdsdgqdllftnqlkehptdfsvefl
eqnsnevqevfakafayyiepqhrdvlqlyapeafnymdkfneqeinlsleelkdqrmls
ryekwekikqhyqhwsdslseegrgllkklqipiepkkddiihslsqeekellkriqids
sdflsteekeflkklqidilsekekeflkklkldiqpydinqrlqdtgglidspsinldv
rkqykrdiqnidallhqsigstlynkiylyenmninnltatlgadlvdstdntkinrgif
nefkknfkysissnymivdinerpaldnerlkwriqlspdtragylengklilqrnigle
ikdvqiikqsekeyiridakvvpkskidtkiqeaqlninqewnkalglpkytklitfnvh
nryasnivesaylilnewknniqsdlikkvtnylvdgngrfvftditlpniaeqythqde
iyeqvhskglyvpesrsillhgpskgvelrndsegfihefghavddyagylldknqsdlv
tnskkfidifkeegsnltsygrtneaeffaeafrlmhstdhaerlkvqknapktfqfind
qikfiins

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1zxvB (B:)
agghgdvgmhvkekeknkdenkrkdeernktqeehlkeimkhivkievkgeeavkkeaae
kllekvpsdvlemykaiggkiyivdgditkhislealsedkkkikdiygkdallhehyvy
akegyepvlviqssedyventekalnvyyeigkilsrdilskinqpyqkfldvlntikna
sdsdgqdllftnqlkehptdfsvefleqnsnevqevfakafayyiepqhrdvlqlyapea
fnymdkfneqeinlsleelkdqrmlsryekwekikqhyqhwsdslseegrgllkklqipi
epkkddiihslsqeekellkriqidssdflsteekeflkklqidirdslseeekellnri
qvdssnplsekekeflkklkldiqpydinqrlqdtgglidspsinldvrkqykrdiqnid
allhqsigstlynkiylyenmninnltatlgadlvdstdntkinrgifnefkknfkysis
snymivdinerpaldnerlkwriqlspdtragylengklilqrnigleikdvqiikqsek
eyiridakvvpkskidtkiqeaqlninqewnkalglpkytklitfnvhnryasnivesay
lilnewknniqsdlikkvtnylvdgngrfvftditlpniaeqythqdeiyeqvhskglyv
pesrsillhgpskgvelrndsegfihefghavddyagylldknqsdlvtnskkfidifke
egsnltsygrtneaeffaeafrlmhstdhaerlkvqknapktfqfindqikfiins

    Sequence, based on observed residues (ATOM records): (download) 
    >1zxvB (B:)
ernktqeehlkeimkhivkievkgeeavkkeaaekllekvpsdvlemykaiggkiyivdg
ditkhislealsedkkkikdiygkdallhehyvyakegyepvlviqssedyventekaln
vyyeigkilsrdilskinqpyqkfldvlntiknasdsdgqdllftnqlkehptdfsvefl
eqnsnevqevfakafayyiepqhrdvlqlyapeafnymdkfneqeinlsleelkdqrmls
ryekwekikqhyqhwsdslseegrgllkklqipiepkkddiihslsqeekellkriqids
sdflsteekeflkklqidirdsdssnplsekekeflkklkldiqpydinqrlqdtgglid
spsinldvrkqykrdiqnidallhqsigstlynkiylyenmninnltatlgadlvdstdn
tkinrgifnefkknfkysissnymivdinerpaldnerlkwriqlspdtragylengkli
lqrnigleikdvqiikqsekeyiridakvvpkskidtkiqeaqlninqewnkalglpkyt
klitfnvhnryasnivesaylilnewknniqsdlikkvtnylvdgngrfvftditlpnia
eqythqdeiyeqvhskglyvpesrsillhgpskgvelrndsegfihefghavddyagyll
dknqsdlvtnskkfidifkeegsnltsygrtneaeffaeafrlmhstdhaerlkvqknap
ktfqfindqikfiins