PDB entry 1k75

View 1k75 on RCSB PDB site
Description: The L-histidinol dehydrogenase (hisD) structure implicates domain swapping and gene duplication.
Class: oxidoreductase
Keywords: L-histidinol dehydrogenase, homodimer, Rossmann fold, 4 domains, hisD, L-histidine biosynthesis, NAD cofactor, Montreal-Kingston Bacterial Structural Genomics Initiative, BSGI, Structural Genomics, OXIDOREDUCTASE
Deposited on 2001-10-18, released 2002-02-27
The last revision prior to the SCOPe 2.07 freeze date was dated 2014-11-12, with a file datestamp of 2014-11-07.
Experiment type: XRAY
Resolution: 1.75 Å
R-factor: 0.19
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: L-histidinol dehydrogenase
    Species: Escherichia coli [TaxId:562]
    Gene: hisD
    Database cross-references and differences (RAF-indexed):
    • Uniprot P06988 (Start-433)
      • conflict (14)
      • modified residue (21)
      • modified residue (87)
      • modified residue (143)
      • conflict (149)
      • modified residue (231)
      • modified residue (276)
      • conflict (312)
      • modified residue (389)
      • conflict (402)
    Domains in SCOPe 2.07: d1k75a_
  • Chain 'B':
    Compound: L-histidinol dehydrogenase
    Species: Escherichia coli [TaxId:562]
    Gene: hisD
    Database cross-references and differences (RAF-indexed):
    • Uniprot P06988 (Start-433)
      • conflict (14)
      • modified residue (21)
      • modified residue (87)
      • modified residue (143)
      • conflict (149)
      • modified residue (231)
      • modified residue (276)
      • conflict (312)
      • modified residue (389)
      • conflict (402)
    Domains in SCOPe 2.07: d1k75b_
  • Heterogens: SO4, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1k75A (A:)
msfntiidwnsctaeqqrqllmrpaisasesitrtvndildnvkargdealreysakfdk
ttvtalkvsaeeiaaaserlsdelkqamavavknietfhtaqklppvdvetqpgvrcqqv
trpvasvglyipggsaplfstvlmlatpasiagckkvvlcspppiadeilyaaqlcgvqd
vfnvggaqaiaalafgtesvpkvdkifgpgnafvteakrqvsqrldgaaidmpagpsevl
viadsgatpdfvasdllsqaehgpdsqvilltpaadmarrvaeaverqlaelpraetarq
alnasrlivtkdlaqcveisnqygpehliiqtrnarelvdsitsagsvflgdwspesagd
yasgtnhvlptygytatcsslgladfqkrmtvqelskegfsalastietlaaaerltahk
navtlrvnalkeqa

    Sequence, based on observed residues (ATOM records): (download) 
    >1k75A (A:)
ntiidwnsctaeqqrqllmrpaisasesitrtvndildnvkargdealreysakfdkttv
talkvsaeeiaaaserlsdelkqamavavknietfhtaqklppvdvetqpgvrcqqvtrp
vasvglyipggsaplfstvlmlatpasiagckkvvlcspppiadeilyaaqlcgvqdvfn
vggaqaiaalafgtesvpkvdkifgpgnafvteakrqvsqrldgaaidmpagpsevlvia
dsgatpdfvasdllsqaehgpdsqvilltpaadmarrvaeaverqlaelpraetarqaln
asrlivtkdlaqcveisnqygpehliiqtrnarelvdsitsagsvflgdwspesagdyas
gtnhvlptygytatcsslgladfqkrmtvqelskegfsalastietlaaaerltahknav
tlrvnalkeqa

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1k75B (B:)
msfntiidwnsctaeqqrqllmrpaisasesitrtvndildnvkargdealreysakfdk
ttvtalkvsaeeiaaaserlsdelkqamavavknietfhtaqklppvdvetqpgvrcqqv
trpvasvglyipggsaplfstvlmlatpasiagckkvvlcspppiadeilyaaqlcgvqd
vfnvggaqaiaalafgtesvpkvdkifgpgnafvteakrqvsqrldgaaidmpagpsevl
viadsgatpdfvasdllsqaehgpdsqvilltpaadmarrvaeaverqlaelpraetarq
alnasrlivtkdlaqcveisnqygpehliiqtrnarelvdsitsagsvflgdwspesagd
yasgtnhvlptygytatcsslgladfqkrmtvqelskegfsalastietlaaaerltahk
navtlrvnalkeqa

    Sequence, based on observed residues (ATOM records): (download) 
    >1k75B (B:)
ntiidwnsctaeqqrqllmrpaisasesitrtvndildnvkargdealreysakfdkttv
talkvsaeeiaaaserlsdelkqamavavknietfhtaqklppvdvetqpgvrcqqvtrp
vasvglyipggsaplfstvlmlatpasiagckkvvlcspppiadeilyaaqlcgvqdvfn
vggaqaiaalafgtesvpkvdkifgpgnafvteakrqvsqrldgaaidmpagpsevlvia
dsgatpdfvasdllsqaehgpdsqvilltpaadmarrvaeaverqlaelpraetarqaln
asrlivtkdlaqcveisnqygpehliiqtrnarelvdsitsagsvflgdwspesagdyas
gtnhvlptygytatcsslgladfqkrmtvqelskegfsalastietlaaaerltahknav
tlrvnalkeqa