PDB entry 1de4

View 1de4 on RCSB PDB site
Description: hemochromatosis protein hfe complexed with transferrin receptor
Class: metal transport inhibitor/receptor
Keywords: hfe, hereditary hemochromatosis, MHC class I, transferrin receptor, metal transport inhibitor-receptor complex
Deposited on 1999-11-12, released 2000-01-19
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.231
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: hemochromatosis protein
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d1de4a1, d1de4a2
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d1de4b_
  • Chain 'C':
    Compound: transferrin receptor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d1de4c1, d1de4c2, d1de4c3
  • Chain 'D':
    Compound: hemochromatosis protein
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d1de4d1, d1de4d2
  • Chain 'E':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d1de4e_
  • Chain 'F':
    Compound: transferrin receptor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d1de4f1, d1de4f2, d1de4f3
  • Chain 'G':
    Compound: hemochromatosis protein
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d1de4g1, d1de4g2
  • Chain 'H':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d1de4h_
  • Chain 'I':
    Compound: transferrin receptor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d1de4i1, d1de4i2, d1de4i3
  • Heterogens: NAG, CA, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1de4A (A:)
    rllrshslhylfmgaseqdlglslfealgyvddqlfvfydhesrrveprtpwvssrissq
    mwlqlsqslkgwdhmftvdfwtimenhnhskeshtlqvilgcemqednstegywkygydg
    qdhlefcpdtldwraaeprawptklewerhkirarqnraylerdcpaqlqqllelgrgvl
    dqqvpplvkvthhvtssvttlrcralnyypqnitmkwlkdkqpmdakefepkdvlpngdg
    tyqgwitlavppgeeqrytcqvehpgldqpliviw
    

    Sequence, based on observed residues (ATOM records): (download)
    >1de4A (A:)
    rshslhylfmgaseqdlglslfealgyvddqlfvfydhesrrveprtpwvssrissqmwl
    qlsqslkgwdhmftvdfwtimenhnhskeshtlqvilgcemqednstegywkygydgqdh
    lefcpdtldwraaeprawptklewerhkirarqnraylerdcpaqlqqllelgrgvldqq
    vpplvkvthhvtssvttlrcralnyypqnitmkwlkdkqpmdakefepkdvlpngdgtyq
    gwitlavppgeeqrytcqvehpgldqpliviw
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1de4B (B:)
    iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
    sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >1de4C (C:)
    rlywddlkrklsekldstdftstikllnensyvpreagsqkdenlalyvenqfrefklsk
    vwrdqhfvkiqvkdsaqnsviivdkngrlvylvenpggyvayskaatvtgklvhanfgtk
    kdfedlytpvngsivivragkitfaekvanaeslnaigvliymdqtkfpivnaelsffgh
    ahlgtgdpytpgfpsfnhtqfppsrssglpnipvqtisraaaeklfgnmegdcpsdwktd
    stcrmvtsesknvkltvsnvlkeikilnifgvikgfvepdhyvvvgaqrdawgpgaaksg
    vgtalllklaqmfsdmvlkdgfqpsrsiifaswsagdfgsvgatewlegylsslhlkaft
    yinldkavlgtsnfkvsaspllytliektmqnvkhpvtgqflyqdsnwaskvekltldna
    afpflaysgipavsfcfcedtdypylgttmdtykelieripelnkvaraaaevagqfvik
    lthdvelnldyerynsqllsfvrdlnqyradikemglslqwlysargdffratsrlttdf
    gnaektdrfvmkklndrvmrveyhflspyvspkespfrhvfwgsgshtlpallenlklrk
    qnngafnetlfrnqlalatwtiqgaanalsgdvwdidnef
    

    Sequence, based on observed residues (ATOM records): (download)
    >1de4C (C:)
    lywddlkrklsekldstdftstikllnensyvpreagsqkdenlalyvenqfrefklskv
    wrdqhfvkiqvkdsaqnsviivdkngrlvylvenpggyvayskaatvtgklvhanfgtkk
    dfedlytpvngsivivragkitfaekvanaeslnaigvliymdqtkfpivnaelsffgha
    hlgtgdpytpgfpsfnhtqfppsrssglpnipvqtisraaaeklfgnmegdcpsdwktds
    tcrmvtsesknvkltvsnvlkeikilnifgvikgfvepdhyvvvgaqrdawgpgaaksgv
    gtalllklaqmfsdmvlkdgfqpsrsiifaswsagdfgsvgatewlegylsslhlkafty
    inldkavlgtsnfkvsaspllytliektmqnvkhpvtgqflyqdsnwaskvekltldnaa
    fpflaysgipavsfcfcedtdypylgttmdtykelieripelnkvaraaaevagqfvikl
    thdvelnldyerynsqllsfvrdlnqyradikemglslqwlysargdffratsrlttdfg
    naektdrfvmkklndrvmrveyhflspyvspkespfrhvfwgsgshtlpallenlklrkq
    nngafnetlfrnqlalatwtiqgaanalsgdvwdi
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >1de4D (D:)
    rllrshslhylfmgaseqdlglslfealgyvddqlfvfydhesrrveprtpwvssrissq
    mwlqlsqslkgwdhmftvdfwtimenhnhskeshtlqvilgcemqednstegywkygydg
    qdhlefcpdtldwraaeprawptklewerhkirarqnraylerdcpaqlqqllelgrgvl
    dqqvpplvkvthhvtssvttlrcralnyypqnitmkwlkdkqpmdakefepkdvlpngdg
    tyqgwitlavppgeeqrytcqvehpgldqpliviw
    

    Sequence, based on observed residues (ATOM records): (download)
    >1de4D (D:)
    rshslhylfmgaseqdlglslfealgyvddqlfvfydhesrrveprtpwvssrissqmwl
    qlsqslkgwdhmftvdfwtimenhnhskeshtlqvilgcemqednstegywkygydgqdh
    lefcpdtldwraaeprawptklewerhkirarqnraylerdcpaqlqqllelgrgvldqq
    vpplvkvthhvtssvttlrcralnyypqnitmkwlkdkqpmdakefepkdvlpngdgtyq
    gwitlavppgeeqrytcqvehpgldqpliviw
    

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1de4E (E:)
    iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
    sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >1de4F (F:)
    rlywddlkrklsekldstdftstikllnensyvpreagsqkdenlalyvenqfrefklsk
    vwrdqhfvkiqvkdsaqnsviivdkngrlvylvenpggyvayskaatvtgklvhanfgtk
    kdfedlytpvngsivivragkitfaekvanaeslnaigvliymdqtkfpivnaelsffgh
    ahlgtgdpytpgfpsfnhtqfppsrssglpnipvqtisraaaeklfgnmegdcpsdwktd
    stcrmvtsesknvkltvsnvlkeikilnifgvikgfvepdhyvvvgaqrdawgpgaaksg
    vgtalllklaqmfsdmvlkdgfqpsrsiifaswsagdfgsvgatewlegylsslhlkaft
    yinldkavlgtsnfkvsaspllytliektmqnvkhpvtgqflyqdsnwaskvekltldna
    afpflaysgipavsfcfcedtdypylgttmdtykelieripelnkvaraaaevagqfvik
    lthdvelnldyerynsqllsfvrdlnqyradikemglslqwlysargdffratsrlttdf
    gnaektdrfvmkklndrvmrveyhflspyvspkespfrhvfwgsgshtlpallenlklrk
    qnngafnetlfrnqlalatwtiqgaanalsgdvwdidnef
    

    Sequence, based on observed residues (ATOM records): (download)
    >1de4F (F:)
    lywddlkrklsekldstdftstikllnensyvpreagsqkdenlalyvenqfrefklskv
    wrdqhfvkiqvkdsaqnsviivdkngrlvylvenpggyvayskaatvtgklvhanfgtkk
    dfedlytpvngsivivragkitfaekvanaeslnaigvliymdqtkfpivnaelsffgha
    hlgtgdpytpgfpsfnhtqfppsrssglpnipvqtisraaaeklfgnmegdcpsdwktds
    tcrmvtsesknvkltvsnvlkeikilnifgvikgfvepdhyvvvgaqrdawgpgaaksgv
    gtalllklaqmfsdmvlkdgfqpsrsiifaswsagdfgsvgatewlegylsslhlkafty
    inldkavlgtsnfkvsaspllytliektmqnvkhpvtgqflyqdsnwaskvekltldnaa
    fpflaysgipavsfcfcedtdypylgttmdtykelieripelnkvaraaaevagqfvikl
    thdvelnldyerynsqllsfvrdlnqyradikemglslqwlysargdffratsrlttdfg
    naektdrfvmkklndrvmrveyhflspyvspkespfrhvfwgsgshtlpallenlklrkq
    nngafnetlfrnqlalatwtiqgaanalsgdvwdi
    

  • Chain 'G':
    Sequence, based on SEQRES records: (download)
    >1de4G (G:)
    rllrshslhylfmgaseqdlglslfealgyvddqlfvfydhesrrveprtpwvssrissq
    mwlqlsqslkgwdhmftvdfwtimenhnhskeshtlqvilgcemqednstegywkygydg
    qdhlefcpdtldwraaeprawptklewerhkirarqnraylerdcpaqlqqllelgrgvl
    dqqvpplvkvthhvtssvttlrcralnyypqnitmkwlkdkqpmdakefepkdvlpngdg
    tyqgwitlavppgeeqrytcqvehpgldqpliviw
    

    Sequence, based on observed residues (ATOM records): (download)
    >1de4G (G:)
    rshslhylfmgaseqdlglslfealgyvddqlfvfydhesrrveprtpwvssrissqmwl
    qlsqslkgwdhmftvdfwtimenhnhskeshtlqvilgcemqednstegywkygydgqdh
    lefcpdtldwraaeprawptklewerhkirarqnraylerdcpaqlqqllelgrgvldqq
    vpplvkvthhvtssvttlrcralnyypqnitmkwlkdkqpmdakefepkdvlpngdgtyq
    gwitlavppgeeqrytcqvehpgldqpliviw
    

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1de4H (H:)
    iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
    sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'I':
    Sequence, based on SEQRES records: (download)
    >1de4I (I:)
    rlywddlkrklsekldstdftstikllnensyvpreagsqkdenlalyvenqfrefklsk
    vwrdqhfvkiqvkdsaqnsviivdkngrlvylvenpggyvayskaatvtgklvhanfgtk
    kdfedlytpvngsivivragkitfaekvanaeslnaigvliymdqtkfpivnaelsffgh
    ahlgtgdpytpgfpsfnhtqfppsrssglpnipvqtisraaaeklfgnmegdcpsdwktd
    stcrmvtsesknvkltvsnvlkeikilnifgvikgfvepdhyvvvgaqrdawgpgaaksg
    vgtalllklaqmfsdmvlkdgfqpsrsiifaswsagdfgsvgatewlegylsslhlkaft
    yinldkavlgtsnfkvsaspllytliektmqnvkhpvtgqflyqdsnwaskvekltldna
    afpflaysgipavsfcfcedtdypylgttmdtykelieripelnkvaraaaevagqfvik
    lthdvelnldyerynsqllsfvrdlnqyradikemglslqwlysargdffratsrlttdf
    gnaektdrfvmkklndrvmrveyhflspyvspkespfrhvfwgsgshtlpallenlklrk
    qnngafnetlfrnqlalatwtiqgaanalsgdvwdidnef
    

    Sequence, based on observed residues (ATOM records): (download)
    >1de4I (I:)
    lywddlkrklsekldstdftstikllnensyvpreagsqkdenlalyvenqfrefklskv
    wrdqhfvkiqvkdsaqnsviivdkngrlvylvenpggyvayskaatvtgklvhanfgtkk
    dfedlytpvngsivivragkitfaekvanaeslnaigvliymdqtkfpivnaelsffgha
    hlgtgdpytpgfpsfnhtqfppsrssglpnipvqtisraaaeklfgnmegdcpsdwktds
    tcrmvtsesknvkltvsnvlkeikilnifgvikgfvepdhyvvvgaqrdawgpgaaksgv
    gtalllklaqmfsdmvlkdgfqpsrsiifaswsagdfgsvgatewlegylsslhlkafty
    inldkavlgtsnfkvsaspllytliektmqnvkhpvtgqflyqdsnwaskvekltldnaa
    fpflaysgipavsfcfcedtdypylgttmdtykelieripelnkvaraaaevagqfvikl
    thdvelnldyerynsqllsfvrdlnqyradikemglslqwlysargdffratsrlttdfg
    naektdrfvmkklndrvmrveyhflspyvspkespfrhvfwgsgshtlpallenlklrkq
    nngafnetlfrnqlalatwtiqgaanalsgdvwdi