SCOPe 2.02: Domain d1pwpa3: 1pwp A:264-550

Lineage for d1pwpa3 (1pwp A:264-550)

1. Root: SCOPe 2.02

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.166: ADP-ribosylation [56398] (1 superfamily)
   unusual fold

4. Superfamily d.166.1: ADP-ribosylation [56399] (8 families)

5. Family d.166.1.1: ADP-ribosylating toxins [56400] (10 proteins)

6. Protein Anthrax toxin lethal factor, middle domain [69845] (1 species)
   includes an all-alpha insert subdomain

7. Species Anthrax bacillus (Bacillus anthracis) [TaxId:1392] [69846] (9 PDB entries)

8. Domain d1pwpa3: 1pwp A:264-550 [95234]
   Other proteins in same PDB: d1pwpa1, d1pwpa2, d1pwpb1, d1pwpb2
   complexed with small molecule inhibitor
   complexed with nsc, zn

Details for d1pwpa3

PDB Entry: 1pwp, 2.9 Å

PDB Description: Crystal Structure of the Anthrax Lethal Factor complexed with Small Molecule Inhibitor NSC 12155

PDB Compounds: (A:) Lethal Factor

SCOPe Domain Sequences for d1pwpa3:

Sequence, based on SEQRES records:

>d1pwpa3 d.166.1.1 (A:264-550) Anthrax toxin lethal factor, middle domain {Anthrax bacillus (Bacillus anthracis) [TaxId: 1392]}
mlsryekwekikqhyqhwsdslseegrgllkklqipiepkkddiihslsqeekellkriq
idssdflsteekeflkklqidirdslseeekellnriqvdssnplsekekeflkklkldi
qpydinqrlqdtgglidspsinldvrkqykrdiqnidallhqsigstlynkiylyenmni
nnltatlgadlvdstdntkinrgifnefkknfkysissnymivdinerpaldnerlkwri
qlspdtragylengklilqrnigleikdvqiikqsekeyiridakvv

Sequence, based on observed residues (ATOM records):

>d1pwpa3 d.166.1.1 (A:264-550) Anthrax toxin lethal factor, middle domain {Anthrax bacillus (Bacillus anthracis) [TaxId: 1392]}
mlsryekwekikqhyqhwsdslseegrgllkklqipiepkkddiihslsqeekellkriq
idssdflsteekeflkklqidirdslsnplsekekeflkklkldiqpydinqrlqdtggl
idspsinldvrkqykrdiqnidallhqsigstlynkiylyenmninnltatlgadlvdst
dntkinrgifnefkknfkysissnymivdinerpaldnerlkwriqlspdtragylengk
lilqrnigleikdvqiikqsekeyiridakvv

Timeline for d1pwpa3:

• d1pwpa3 first appeared in SCOP 1.67
  
• d1pwpa3 appears in SCOPe 2.01
  
• d1pwpa3 appears in SCOPe 2.03
  
• d1pwpa3 appears in the current release, SCOPe 2.08