SCOPe 2.05: Domain d1p0pa_: 1p0p A:

Lineage for d1p0pa_ (1p0p A:)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.69: alpha/beta-Hydrolases [53473] (1 superfamily)
   core: 3 layers, a/b/a; mixed beta-sheet of 8 strands, order 12435678, strand 2 is antiparallel to the rest

4. Superfamily c.69.1: alpha/beta-Hydrolases [53474] (42 families)
   many members have left-handed crossover connection between strand 8 and additional strand 9

5. Family c.69.1.1: Acetylcholinesterase-like [53475] (6 proteins)
   automatically mapped to Pfam PF00135

6. Protein Butyryl cholinesterase [102612] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [102613] (6 PDB entries)

8. Domain d1p0pa_: 1p0p A: [93869]
   complexed with bch, cl, gol, nag, so4, vxa

Details for d1p0pa_

PDB Entry: 1p0p, 2.3 Å

PDB Description: crystal structure of soman-aged human butyryl cholinesterase in complex with the substrate analog butyrylthiocholine

PDB Compounds: (A:) cholinesterase

SCOPe Domain Sequences for d1p0pa_:

Sequence, based on SEQRES records:

>d1p0pa_ c.69.1.1 (A:) Butyryl cholinesterase {Human (Homo sapiens) [TaxId: 9606]}
iiiatkngkvrgmqltvfggtvtaflgipyaqpplgrlrfkkpqsltkwsdiwnatkyan
sccqnidqsfpgfhgsemwnpntdlsedclylnvwipapkpknatvliwiygggfqtgts
slhvydgkflarvervivvsmnyrvgalgflalpgnpeapgnmglfdqqlalqwvqknia
afggnpksvtlfgesagaasvslhllspgshslftrailqsgsfnapwavtslyearnrt
lnlakltgcsreneteiikclrnkdpqeillneafvvpygtplsvnfgptvdgdfltdmp
dillelgqfkktqilvgvnkdegtaflvygapgfskdnnsiitrkefqeglkiffpgvse
fgkesilfhytdwvddqrpenyrealgdvvgdynficpaleftkkfsewgnnaffyyfeh
rssklpwpewmgvmhgyeiefvfglplerrdqytkaeeilsrsivkrwanfakygnpqet
qnqstswpvfksteqkyltlntestrimtklraqqcrfwtsffpkv

Sequence, based on observed residues (ATOM records):

>d1p0pa_ c.69.1.1 (A:) Butyryl cholinesterase {Human (Homo sapiens) [TaxId: 9606]}
iiiatkngkvrgmqltvfggtvtaflgipyaqpplgrlrfkkpqsltkwsdiwnatkyan
sccqnidqsfpgfhgsemwnpntdlsedclylnvwipapkpknatvliwiygggfqtgts
slhvydgkflarvervivvsmnyrvgalgflalpgnpeapgnmglfdqqlalqwvqknia
afggnpksvtlfgesagaasvslhllspgshslftrailqsgsfnapwavtslyearnrt
lnlakltgcsrneteiikclrnkdpqeillneafvvpygtplsvnfgptvdgdfltdmpd
illelgqfkktqilvgvnkdegtaflvygapgfskdnnsiitrkefqeglkiffpgvsef
gkesilfhytdwvqrpenyrealgdvvgdynficpaleftkkfsewgnnaffyyfehrss
klpwpewmgvmhgyeiefvfglplerrdytkaeeilsrsivkrwanfakygnpqetqnqs
tswpvfksteqkyltlntestrimtklraqqcrfwtsffpkv

Timeline for d1p0pa_:

• d1p0pa_ first appeared in SCOP 1.67
  
• d1p0pa_ appears in SCOPe 2.04
  
• d1p0pa_ appears in SCOPe 2.06
  
• d1p0pa_ appears in the current release, SCOPe 2.08