SCOPe 2.01: Domain d1i3lb_: 1i3l B:

Lineage for d1i3lb_ (1i3l B:)

1. Root: SCOPe 2.01

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein Uridine diphosphogalactose-4-epimerase (UDP-galactose 4-epimerase) [51752] (4 species)

7. Species Human (Homo sapiens) [TaxId:9606] [51754] (7 PDB entries)

8. Domain d1i3lb_: 1i3l B: [61598]
   complexed with cl, edo, gdu, mg, nad

Details for d1i3lb_

PDB Entry: 1i3l, 1.5 Å

PDB Description: molecular basis for severe epimerase-deficiency galactosemia: x-ray structure of the human v94m-substituted udp-galactose 4-epimerase

PDB Compounds: (B:) UDP-glucose 4-epimerase

SCOPe Domain Sequences for d1i3lb_:

Sequence; same for both SEQRES and ATOM records:

>d1i3lb_ c.2.1.2 (B:) Uridine diphosphogalactose-4-epimerase (UDP-galactose 4-epimerase) {Human (Homo sapiens) [TaxId: 9606]}
aekvlvtggagyigshtvlelleagylpvvidnfhnafrgggslpeslrrvqeltgrsve
feemdildqgalqrlfkkysfmavihfaglkamgesvqkpldyyrvnltgtiqlleimka
hgvknlvfsssatvygnpqylpldeahptggctnpygkskffieemirdlcqadktwnvv
llryfnptgahasgcigedpqgipnnlmpyvsqvaigrrealnvfgndydtedgtgvrdy
ihvvdlakghiaalrklkeqcgcriynlgtgtgysvlqmvqamekasgkkipykvvarre
gdvaacyanpslaqeelgwtaalgldrmcedlwrwqkqnpsgfgt

Timeline for d1i3lb_:

• d1i3lb_ first appeared in SCOP 1.57
  
• d1i3lb_ appears in SCOP 1.75
  
• d1i3lb_ appears in SCOPe 2.02
  
• d1i3lb_ appears in the current release, SCOPe 2.08