SCOPe 2.08: Species: Human (Homo sapiens) [TaxId: 9606]

Lineage for Species: Human (Homo sapiens) [TaxId: 9606]

Root: SCOPe 2.08
Class g: Small proteins [56992] (100 folds)
Fold g.1: Insulin-like [56993] (1 superfamily)
nearly all-alpha
can be classified as disulfide-rich
Superfamily g.1.1: Insulin-like [56994] (1 family)
Family g.1.1.1: Insulin-like [56995] (5 proteins)
Protein Insulin [56996] (3 species)
Species Human (Homo sapiens) [TaxId:9606] [56998] (63 PDB entries)
Uniprot P01308

PDB entries in Species: Human (Homo sapiens) [TaxId: 9606]:

Domain(s) for 1a7f:
- Domain d1a7f.1: 1a7f B:,A: [43943]
  mutant
Domain(s) for 1ai0:
1. Domain d1ai0.1: 1ai0 B:,A: [43924]
  complexed with iph, zn
2. Domain d1ai0.2: 1ai0 D:,C: [43925]
  complexed with iph, zn
3. Domain d1ai0.3: 1ai0 F:,E: [43926]
  complexed with iph, zn
4. Domain d1ai0.4: 1ai0 H:,G: [43927]
  complexed with iph, zn
5. Domain d1ai0.5: 1ai0 J:,I: [43928]
  complexed with iph, zn
6. Domain d1ai0.6: 1ai0 L:,K: [43929]
  complexed with iph, zn
Domain(s) for 1aiy:
1. Domain d1aiy.1: 1aiy B:,A: [43930]
  complexed with iph, zn
2. Domain d1aiy.2: 1aiy D:,C: [43931]
  complexed with iph, zn
3. Domain d1aiy.3: 1aiy F:,E: [43932]
  complexed with iph, zn
4. Domain d1aiy.4: 1aiy H:,G: [43933]
  complexed with iph, zn
5. Domain d1aiy.5: 1aiy J:,I: [43934]
  complexed with iph, zn
6. Domain d1aiy.6: 1aiy L:,K: [43935]
  complexed with iph, zn
Domain(s) for 1b9e:
1. Domain d1b9e.1: 1b9e B:,A: [43885]
  mutant
2. Domain d1b9e.2: 1b9e D:,C: [43886]
  mutant
Domain(s) for 1ben:
1. Domain d1ben.1: 1ben B:,A: [43837]
  complexed with cl, hbd, zn
2. Domain d1ben.2: 1ben D:,C: [43838]
  complexed with cl, hbd, zn
Domain(s) for 1bzv:
- Domain d1bzv.1: 1bzv B:,A: [43942]
  superpotent single-replacement insulin analogue
Domain(s) for 1efe:
- Domain d1efea_: 1efe A: [43891]
  an active mini-proinsulin, m2pi
Domain(s) for 1ev3:
1. Domain d1ev3.1: 1ev3 B:,A: [43845]
  complexed with cl, crs, zn
2. Domain d1ev3.2: 1ev3 D:,C: [43846]
  complexed with cl, crs, zn
Domain(s) for 1ev6:
1. Domain d1ev6.1: 1ev6 B:,A: [43857]
  complexed with cl, crs, na, zn
2. Domain d1ev6.2: 1ev6 D:,C: [43858]
  complexed with cl, crs, na, zn
3. Domain d1ev6.3: 1ev6 F:,E: [43859]
  complexed with cl, crs, na, zn
4. Domain d1ev6.4: 1ev6 H:,G: [43860]
  complexed with cl, crs, na, zn
5. Domain d1ev6.5: 1ev6 J:,I: [43861]
  complexed with cl, crs, na, zn
6. Domain d1ev6.6: 1ev6 L:,K: [43862]
  complexed with cl, crs, na, zn
Domain(s) for 1evr:
1. Domain d1evr.1: 1evr B:,A: [43851]
  complexed with cl, na, rco, zn
2. Domain d1evr.2: 1evr D:,C: [43852]
  complexed with cl, na, rco, zn
3. Domain d1evr.3: 1evr F:,E: [43853]
  complexed with cl, na, rco, zn
4. Domain d1evr.4: 1evr H:,G: [43854]
  complexed with cl, na, rco, zn
5. Domain d1evr.5: 1evr J:,I: [43855]
  complexed with cl, na, rco, zn
6. Domain d1evr.6: 1evr L:,K: [43856]
  complexed with cl, na, rco, zn
Domain(s) for 1fu2:
1. Domain d1fu2.1: 1fu2 B:,A: [43906]
  complexed with cl, na, zn
2. Domain d1fu2.2: 1fu2 D:,C: [43907]
  complexed with cl, na, zn
3. Domain d1fu2.3: 1fu2 F:,E: [43908]
  complexed with cl, na, zn
4. Domain d1fu2.4: 1fu2 H:,G: [43909]
  complexed with cl, na, zn
Domain(s) for 1fub:
1. Domain d1fub.1: 1fub B:,A: [43892]
  complexed with cl, na, zn
2. Domain d1fub.2: 1fub D:,C: [43893]
  complexed with cl, na, zn
Domain(s) for 1g7a:
1. Domain d1g7a.1: 1g7a B:,A: [60322]
  complexed with acn, cl, gol, zn
2. Domain d1g7a.2: 1g7a D:,C: [60323]
  complexed with acn, cl, gol, zn
3. Domain d1g7a.3: 1g7a F:,E: [60324]
  complexed with acn, cl, gol, zn
4. Domain d1g7a.4: 1g7a H:,G: [60325]
  complexed with acn, cl, gol, zn
Domain(s) for 1g7b:
1. Domain d1g7b.1: 1g7b B:,A: [60326]
  complexed with acn, cl, gol, zn
2. Domain d1g7b.2: 1g7b D:,C: [60327]
  complexed with acn, cl, gol, zn
3. Domain d1g7b.3: 1g7b F:,E: [60328]
  complexed with acn, cl, gol, zn
4. Domain d1g7b.4: 1g7b H:,G: [60329]
  complexed with acn, cl, gol, zn
Domain(s) for 1guj:
1. Domain d1guj.1: 1guj B:,A: [70582]
  structure at pH 2: the conditions promoting insulin fibre formation
  complexed with so4
2. Domain d1guj.2: 1guj D:,C: [70583]
  structure at pH 2: the conditions promoting insulin fibre formation
  complexed with so4
Domain(s) for 1hiq:
- Domain d1hiq.1: 1hiq B:,A: [43936]
  mutant
Domain(s) for 1his:
- Domain d1his.1: 1his B:,A: [43938]
Domain(s) for 1hit:
- Domain d1hit.1: 1hit B:,A: [43937]
  mutant
Domain(s) for 1hls:
- Domain d1hls.1: 1hls B:,A: [43910]
Domain(s) for 1htv:
1. Domain d1htv.1: 1htv B:,A: [61255]
  complexed with zn
2. Domain d1htv.2: 1htv D:,C: [61256]
  complexed with zn
3. Domain d1htv.3: 1htv F:,E: [61257]
  complexed with zn
4. Domain d1htv.4: 1htv H:,G: [61258]
  complexed with zn
5. Domain d1htv.5: 1htv J:,I: [61259]
  complexed with zn
6. Domain d1htv.6: 1htv L:,K: [61260]
  complexed with zn
Domain(s) for 1hui:
- Domain d1hui.1: 1hui B:,A: [43940]
  mutant
Domain(s) for 1iog:
- Domain d1iog.1: 1iog B:,A: [43944]
  mutant
Domain(s) for 1ioh:
- Domain d1ioh.1: 1ioh B:,A: [43941]
  mutant
Domain(s) for 1j73:
1. Domain d1j73.1: 1j73 B:,A: [62670]
  an unstable insulin analog with native activity
  complexed with zn
2. Domain d1j73.2: 1j73 D:,C: [62671]
  an unstable insulin analog with native activity
  complexed with zn
Domain(s) for 1jca:
1. Domain d1jca.1: 1jca B:,A: [62874]
  an unstable insulin analog with enhanced(?) activity
  complexed with zn
2. Domain d1jca.2: 1jca D:,C: [62875]
  an unstable insulin analog with enhanced(?) activity
  complexed with zn
Domain(s) for 1jco:
- Domain d1jco.1: 1jco B:,A: [66503]
  a monomeric mutant (PT insulin)
  Alpha-galactosidase agl1
  mutant
Domain(s) for 1k3m:
- Domain d1k3m.1: 1k3m B:,A: [68117]
  mutant
Domain(s) for 1kmf:
- Domain d1kmf.1: 1kmf B:,A: [68694]
  mutant
Domain(s) for 1lkq:
- Domain d1lkq.1: 1lkq B:,A: [73979]
  mutant
Domain(s) for 1lph:
1. Domain d1lph.1: 1lph B:,A: [43887]
  complexed with cl, iph, zn
2. Domain d1lph.2: 1lph D:,C: [43888]
  complexed with cl, iph, zn
Domain(s) for 1mhi:
- Domain d1mhi.1: 1mhi B:,A: [43945]
  mutant
Domain(s) for 1mhj:
- Domain d1mhj.1: 1mhj B:,A: [43947]
  mutant
Domain(s) for 1mso:
1. Domain d1mso.1: 1mso B:,A: [85092]
  complexed with zn
2. Domain d1mso.2: 1mso D:,C: [85093]
  complexed with zn
Domain(s) for 1os3:
1. Domain d1os3.1: 1os3 B:,A: [87372]
  complexed with cl, zn
2. Domain d1os3.2: 1os3 D:,C: [87373]
  complexed with cl, zn
Domain(s) for 1os4:
1. Domain d1os4.1: 1os4 B:,A: [87374]
  complexed with zn
2. Domain d1os4.2: 1os4 D:,C: [87375]
  complexed with zn
3. Domain d1os4.3: 1os4 F:,E: [87376]
  complexed with zn
4. Domain d1os4.4: 1os4 H:,G: [87377]
  complexed with zn
5. Domain d1os4.5: 1os4 J:,I: [87378]
  complexed with zn
6. Domain d1os4.6: 1os4 L:,K: [87379]
  complexed with zn
Domain(s) for 1q4v:
1. Domain d1q4v.1: 1q4v B:,A: [95830]
  complexed with iph, zn
2. Domain d1q4v.2: 1q4v D:,C: [95831]
  complexed with iph, zn
Domain(s) for 1qiy:
1. Domain d1qiy.1: 1qiy B:,A: [43879]
  complexed with cl, iph, zn
2. Domain d1qiy.2: 1qiy D:,C: [43880]
  complexed with cl, iph, zn
3. Domain d1qiy.3: 1qiy F:,E: [43881]
  complexed with cl, iph, zn
4. Domain d1qiy.4: 1qiy H:,G: [43882]
  complexed with cl, iph, zn
5. Domain d1qiy.5: 1qiy J:,I: [43883]
  complexed with cl, iph, zn
6. Domain d1qiy.6: 1qiy L:,K: [43884]
  complexed with cl, iph, zn
Domain(s) for 1qiz:
1. Domain d1qiz.1: 1qiz B:,A: [43873]
  complexed with cl, rco, zn
2. Domain d1qiz.2: 1qiz D:,C: [43874]
  complexed with cl, rco, zn
3. Domain d1qiz.3: 1qiz F:,E: [43875]
  complexed with cl, rco, zn
4. Domain d1qiz.4: 1qiz H:,G: [43876]
  complexed with cl, rco, zn
5. Domain d1qiz.5: 1qiz J:,I: [43877]
  complexed with cl, rco, zn
6. Domain d1qiz.6: 1qiz L:,K: [43878]
  complexed with cl, rco, zn
Domain(s) for 1qj0:
1. Domain d1qj0.1: 1qj0 B:,A: [43889]
  complexed with cl, zn
2. Domain d1qj0.2: 1qj0 D:,C: [43890]
  complexed with cl, zn
Domain(s) for 1sf1:
- Domain d1sf1.1: 1sf1 B:,A: [98827]
  solution structure under amyloidogenic condition
Domain(s) for 1sjt:
- Domain d1sjt.1: 1sjt B:,A: [43946]
  mutant
Domain(s) for 1sju:
- Domain d1sjua_: 1sju A: [43950]
  single chain insulin analog mutant
  mutant
Domain(s) for 1t1k:
- Domain d1t1k.1: 1t1k B:,A: [106251]
  mutant
Domain(s) for 1t1p:
- Domain d1t1p.1: 1t1p B:,A: [106260]
  mutant
Domain(s) for 1t1q:
- Domain d1t1q.1: 1t1q B:,A: [106261]
  mutant
Domain(s) for 1trz:
1. Domain d1trz.1: 1trz B:,A: [43843]
  complexed with cl, na, zn
2. Domain d1trz.2: 1trz D:,C: [43844]
  complexed with cl, na, zn
Domain(s) for 1tyl:
1. Domain d1tyl.1: 1tyl B:,A: [43865]
  complexed with cl, tyl, zn
2. Domain d1tyl.2: 1tyl D:,C: [43866]
  complexed with cl, tyl, zn
Domain(s) for 1tym:
1. Domain d1tym.1: 1tym B:,A: [43863]
  complexed with cl, tyl, zn
2. Domain d1tym.2: 1tym D:,C: [43864]
  complexed with cl, tyl, zn
Domain(s) for 1vkt:
- Domain d1vkt.1: 1vkt B:,A: [43949]
Domain(s) for 1xda:
1. Domain d1xda.1: 1xda B:,A: [43847]
  complexed with cl, iph, myr, zn
2. Domain d1xda.2: 1xda D:,C: [43848]
  complexed with cl, iph, myr, zn
3. Domain d1xda.3: 1xda F:,E: [43849]
  complexed with cl, iph, myr, zn
4. Domain d1xda.4: 1xda H:,G: [43850]
  complexed with cl, iph, myr, zn
Domain(s) for 1xgl:
- Domain d1xgl.1: 1xgl B:,A: [43939]
Domain(s) for 1zeg:
1. Domain d1zeg.1: 1zeg B:,A: [43841]
  complexed with cl, iph, zn
2. Domain d1zeg.2: 1zeg D:,C: [43842]
  complexed with cl, iph, zn
Domain(s) for 1zeh:
1. Domain d1zeh.1: 1zeh B:,A: [43839]
  complexed with cl, crs, zn
2. Domain d1zeh.2: 1zeh D:,C: [43840]
  complexed with cl, crs, zn
Domain(s) for 1znj:
1. Domain d1znj.1: 1znj B:,A: [43867]
  complexed with cl, iph, zn
2. Domain d1znj.2: 1znj D:,C: [43868]
  complexed with cl, iph, zn
3. Domain d1znj.3: 1znj F:,E: [43869]
  complexed with cl, iph, zn
4. Domain d1znj.4: 1znj H:,G: [43870]
  complexed with cl, iph, zn
5. Domain d1znj.5: 1znj J:,I: [43871]
  complexed with cl, iph, zn
6. Domain d1znj.6: 1znj L:,K: [43872]
  complexed with cl, iph, zn
Domain(s) for 2aiy:
1. Domain d2aiy.1: 2aiy B:,A: [43918]
  complexed with iph
2. Domain d2aiy.2: 2aiy D:,C: [43919]
  complexed with iph
3. Domain d2aiy.3: 2aiy F:,E: [43920]
  complexed with iph
4. Domain d2aiy.4: 2aiy H:,G: [43921]
  complexed with iph
5. Domain d2aiy.5: 2aiy J:,I: [43922]
  complexed with iph
6. Domain d2aiy.6: 2aiy L:,K: [43923]
  complexed with iph
Domain(s) for 2hiu:
- Domain d2hiu.1: 2hiu B:,A: [43948]
Domain(s) for 2jmn:
- Domain d2jmn.1: 2jmn B:,A: [166257]
  mutant
Domain(s) for 2lwz:
- Domain d2lwza_: 2lwz A: [344603]
  automated match to d5wbta_
Domain(s) for 3aiy:
1. Domain d3aiy.1: 3aiy B:,A: [43911]
  complexed with iph
2. Domain d3aiy.2: 3aiy D:,C: [43912]
  complexed with iph
3. Domain d3aiy.3: 3aiy F:,E: [43913]
  complexed with iph
4. Domain d3aiy.4: 3aiy H:,G: [43914]
  complexed with iph
5. Domain d3aiy.5: 3aiy J:,I: [43915]
  complexed with iph
6. Domain d3aiy.6: 3aiy L:,K: [43916]
  complexed with iph
Domain(s) for 4aiy:
1. Domain d4aiy.1: 4aiy B:,A: [43900]
  complexed with iph
2. Domain d4aiy.2: 4aiy D:,C: [43901]
  complexed with iph
3. Domain d4aiy.3: 4aiy F:,E: [43902]
  complexed with iph
4. Domain d4aiy.4: 4aiy H:,G: [43903]
  complexed with iph
5. Domain d4aiy.5: 4aiy J:,I: [43904]
  complexed with iph
6. Domain d4aiy.6: 4aiy L:,K: [43905]
  complexed with iph
Domain(s) for 5aiy:
1. Domain d5aiy.1: 5aiy B:,A: [43894]
  complexed with iph
2. Domain d5aiy.2: 5aiy D:,C: [43895]
  complexed with iph
3. Domain d5aiy.3: 5aiy F:,E: [43896]
  complexed with iph
4. Domain d5aiy.4: 5aiy H:,G: [43897]
  complexed with iph
5. Domain d5aiy.5: 5aiy J:,I: [43898]
  complexed with iph
6. Domain d5aiy.6: 5aiy L:,K: [43899]
  complexed with iph
Domain(s) for 5wbt:
- Domain d5wbta_: 5wbt A: [341669]
  automated match to d1efea_
Domain(s) for 6u46:
- Domain d6u46a_: 6u46 A: [392276]
  automated match to d5wbta_

More info for Species Human (Homo sapiens) [TaxId:9606] from g.1.1.1 Insulin

Timeline for Species Human (Homo sapiens) [TaxId:9606] from g.1.1.1 Insulin:

Species Human (Homo sapiens) [TaxId:9606] from g.1.1.1 Insulin first appeared (with stable ids) in SCOP 1.55
Species Human (Homo sapiens) [TaxId:9606] from g.1.1.1 Insulin appears in SCOPe 2.07