SCOPe 2.08: Domain d7m2nc2: 7m2n C:160-331

Lineage for d7m2nc2 (7m2n C:160-331)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.162: LDH C-terminal domain-like [56326] (1 superfamily)
   unusual fold, defines family

4. Superfamily d.162.1: LDH C-terminal domain-like [56327] (3 families)

5. Family d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain [56328] (5 proteins)
   N-terminal domain is NAD-binding module (alpha/beta Rossmann-fold domain)
   automatically mapped to Pfam PF02866

6. Protein Lactate dehydrogenase [56339] (20 species)

7. Species Human (Homo sapiens), muscle isoform (M chain) [TaxId:9606] [64445] (39 PDB entries)

8. Domain d7m2nc2: 7m2n C:160-331 [418356]
   Other proteins in same PDB: d7m2na1, d7m2nb1, d7m2nb3, d7m2nc1, d7m2nd1
   automated match to d4jnka2
   complexed with edo, gol, nai, peg, so4, yoj

Details for d7m2nc2

PDB Entry: 7m2n, 2.5 Å

PDB Description: crystal structure of human lactate dehydrogenase a with inhibitor compound 15

PDB Compounds: (C:) L-lactate dehydrogenase A chain

SCOPe Domain Sequences for d7m2nc2:

Sequence; same for both SEQRES and ATOM records:

>d7m2nc2 d.162.1.1 (C:160-331) Lactate dehydrogenase {Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606]}
sgcnldsarfrylmgerlgvhplschgwvlgehgdssvpvwsgmnvagvslktlhpdlgt
dkdkeqwkevhkqvvesayeviklkgytswaiglsvadlaesimknlrrvhpvstmikgl
ygikddvflsvpcilgqngisdlvkvtltseeearlkksadtlwgiqkelqf

Timeline for d7m2nc2:

• d7m2nc2 is new in SCOPe 2.08-stable