SCOPe 2.08: Domain d3gcwa1: 3gcw A:153-449

Lineage for d3gcwa1 (3gcw A:153-449)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.41: Subtilisin-like [52742] (1 superfamily)
   3 layers: a/b/a, parallel beta-sheet of 7 strands, order 2314567; left-handed crossover connection between strands 2 & 3

4. Superfamily c.41.1: Subtilisin-like [52743] (3 families)

5. Family c.41.1.1: Subtilases [52744] (15 proteins)

6. Protein Proprotein convertase subtilisin/kexin type 9 [419231] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [419292] (20 PDB entries)

8. Domain d3gcwa1: 3gcw A:153-449 [408363]
   Other proteins in same PDB: d3gcwe1, d3gcwe2
   automated match to d2p4ea1
   complexed with ca

Details for d3gcwa1

PDB Entry: 3gcw, 2.7 Å

PDB Description: pcsk9:egfa(h306y)

PDB Compounds: (A:) Proprotein convertase subtilisin/kexin type 9

SCOPe Domain Sequences for d3gcwa1:

Sequence, based on SEQRES records:

>d3gcwa1 c.41.1.1 (A:153-449) Proprotein convertase subtilisin/kexin type 9 {Human (Homo sapiens) [TaxId: 9606]}
sipwnleritppryradeyqppdggslvevylldtsiqsdhreiegrvmvtdfenvpeed
gtrfhrqaskcdshgthlagvvsgrdagvakgasmrslrvlncqgkgtvsgtliglefir
ksqlvqpvgplvvllplaggysrvlnaacqrlaragvvlvtaagnfrddaclyspasape
vitvgatnaqdqpvtlgtlgtnfgrcvdlfapgediigassdcstcfvsqsgtsqaaahv
agiaammlsaepeltlaelrqrlihfsakdvineawfpedqrvltpnlvaalppsth

Sequence, based on observed residues (ATOM records):

>d3gcwa1 c.41.1.1 (A:153-449) Proprotein convertase subtilisin/kexin type 9 {Human (Homo sapiens) [TaxId: 9606]}
sipwnleritppryradeyqgslvevylldtsiqsdhreiegrvmvtdfenvpeeaskcd
shgthlagvvsgrdagvakgasmrslrvlncqgkgtvsgtliglefirksqlvqpvgplv
vllplaggysrvlnaacqrlaragvvlvtaagnfrddaclyspasapevitvgatnaqdq
pvtlgtlgtnfgrcvdlfapgediigassdcstcfvsqsgtsqaaahvagiaammlsaep
eltlaelrqrlihfsakdvineawfpedqrvltpnlvaalppsth

Timeline for d3gcwa1:

• d3gcwa1 is new in SCOPe 2.08-stable