SCOPe 2.08: Domain d7kg7a_: 7kg7 A:

Lineage for d7kg7a_ (7kg7 A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.50: Macro domain-like [52948] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 6 strands, order 165243, strand 3 is antiparallel to the rest

4. Superfamily c.50.1: Macro domain-like [52949] (4 families)

5. Family c.50.1.3: Poly(ADP-ribose) glycohydrolase (PARG) catalytic domain-like [310642] (2 proteins)
   Pfam PF05028
   Contains N- and C-terminal extensions to macrodomain, including Tyr clasp, discussed in PubMed 22609859

6. Protein Poly(ADP-ribose) glycohydrolase (PARG) catalytic domain [310785] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [324080] (19 PDB entries)

8. Domain d7kg7a_: 7kg7 A: [399231]
   automated match to d4fc2d_
   complexed with dms, so4, wdj

Details for d7kg7a_

PDB Entry: 7kg7, 1.85 Å

PDB Description: structure of human parg complexed with parg-292

PDB Compounds: (A:) Poly(ADP-ribose) glycohydrolase

SCOPe Domain Sequences for d7kg7a_:

Sequence, based on SEQRES records:

>d7kg7a_ c.50.1.3 (A:) Poly(ADP-ribose) glycohydrolase (PARG) catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
kkwlgtpieemrrmprcgirlpllrpsanhtvtirvdllragevpkpfpthykdlwdnkh
vkmpcseqnlypvedengertagsrweliqtallnkftrpqnlkdailkynvayskkwdf
talidfwdkvleeaeaqhlyqsilpdmvkialclpnictqpipllaaamnhsitmsqeqi
asllanaffctfprrnakmkseyssypdinfnrlfegrssrkpeklktlfcyfrrvtaaa
ptglvtftrqsledfpewercekpltrlhvtyegtieengqgmlqvdfanrfvgggvtsa
glvqeeirflinpeliisrlftevldhnecliitgteqyseytgyaetyrwsrshedgse
rddwqrrcteivaidalhfrryldqfvpekmrrelnkaycgflrpgvssenlsavatgnw
gcgafggdarlkaliqilaaaaaerdvvyftfgdselmrdiysmhiflterkltvgdvyk
lllryyneecrncstpgpdiklypfiyhaves

Sequence, based on observed residues (ATOM records):

>d7kg7a_ c.50.1.3 (A:) Poly(ADP-ribose) glycohydrolase (PARG) catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
kkwlgtpieemrrmprcgirlpllrpsanhtvtirvdllragevpkpfpthykdlwdnkh
vkmpcseqnlypagsrweliqtallnkftrpqnlkdailkynvayskkwdftalidfwdk
vleeaeaqhlyqsilpdmvkialclpnictqpipllaaamnhsitmsqeqiasllanaff
ctfprrnakmkseyssypdinfnrlfegrssrkpeklktlfcyfrrvtaaaptglvtftr
qsledfpewercekpltrlhvtyegtieengqgmlqvdfanrfvgggvtsaglvqeeirf
linpeliisrlftevldhnecliitgteqyseytgyaetyrwsrshedgserddwqrrct
eivaidalhfrryldqfvpekmrrelnkaycgflrpgvssenlsavatgnwgcgafggda
rlkaliqilaaaaaerdvvyftfgdselmrdiysmhiflterkltvgdvyklllryynee
crncgpdiklypfiyhaves

Timeline for d7kg7a_:

• d7kg7a_ first appeared in SCOPe 2.07