SCOPe 2.07: Domain d5pznb_: 5pzn B:

Lineage for d5pznb_ (5pzn B:)

1. Root: SCOPe 2.07

2. Class e: Multi-domain proteins (alpha and beta) [56572] (71 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (8 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.4: RNA-dependent RNA-polymerase [56694] (3 proteins)

6. Protein automated matches [190260] (25 species)
   not a true protein

7. Species Hepatitis C virus genotype 1b (isolate con1) [TaxId:333284] [188792] (8 PDB entries)

8. Domain d5pznb_: 5pzn B: [334245]
   automated match to d3q0za_
   protein/RNA complex; complexed with 23e, 8xp, gol, so4

Details for d5pznb_

PDB Entry: 5pzn, 2.25 Å

PDB Description: crystal structure of the hepatitis c virus ns5b rna-dependent rna polymerase in complex with 5-[3-(tert-butylcarbamoyl)phenyl]-2-(4- fluorophenyl)-n-methyl-1-benzofuran-3-carboxamide

PDB Compounds: (B:) RNA-directed RNA polymerase

SCOPe Domain Sequences for d5pznb_:

Sequence, based on SEQRES records:

>d5pznb_ e.8.1.4 (B:) automated matches {Hepatitis C virus genotype 1b (isolate con1) [TaxId: 333284]}
smsytwtgalitpcaaeetklpinalsnsllrhhnlvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsarskfgygakdvrnlsskavnhir
svwkdlledtetpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqavmgssygfqyspgqrveflvnawkakkcpmgfaydtrcfdstvtendirveesiy
qccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkaa
aacraaklqdctmlvcgddlvvicesagtqedeaslrafteamtrysappgdppkpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiiqrlhglsafslhsyspg
einrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavrtklkltpip
aasqldlsswfvagysggdiyhsls

Sequence, based on observed residues (ATOM records):

>d5pznb_ e.8.1.4 (B:) automated matches {Hepatitis C virus genotype 1b (isolate con1) [TaxId: 333284]}
smsytwtgalitpcyattsrsaslrqkkvtfdrlqvlddhyrdvlkemkakastvkakll
sveeackltpphsarskfgygakdvrnlsskavnhirsvwkdlledtetpidttimakne
vfcvqpggrkparlivfpdlgvrvcekmalydvvstlpqavmgssygfqyspgqrveflv
nawkakkcpmgfaydtrcfdstvtendirveesiyqccdlapearqairslterlyiggp
ltnskgqncgyrrcrasgvlttscgntltcylkaaaacraaklqdctmlvcgddlvvice
sagtqedeaslrafteamtrysappgdppkpeydlelitscssnvsvahdasgkrvyylt
rdpttplaraawetarhtpvnswlgniimyaptlwarmilmthffsillaqeqlekaldc
qiygacysiepldlpqiiqrlhglsafslhsyspgeinrvasclrklgvpplrvwrhrar
svrarllsqggraatcgkylfnwavrtklkltpipaasqldlsswfvagysggdiyhsls

Timeline for d5pznb_:

• d5pznb_ first appeared in SCOPe 2.06
  
• d5pznb_ appears in the current release, SCOPe 2.08