SCOPe 2.06: Domain d5dy5a1: 5dy5 A:56-356

Lineage for d5dy5a1 (5dy5 A:56-356)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.31: DHS-like NAD/FAD-binding domain [52466] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like

4. Superfamily c.31.1: DHS-like NAD/FAD-binding domain [52467] (7 families)
   binds cofactor molecules in the opposite direction than classical Rossmann fold

5. Family c.31.1.5: Sir2 family of transcriptional regulators [63984] (8 proteins)
   silent information regulator 2; contains insertion of a rubredoxin-like zinc finger domain

6. Protein automated matches [191258] (3 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [189817] (16 PDB entries)

8. Domain d5dy5a1: 5dy5 A:56-356 [313470]
   Other proteins in same PDB: d5dy5a2
   automated match to d1j8fc_
   complexed with 5gr, bu3, edo, epe, zn

Details for d5dy5a1

PDB Entry: 5dy5, 1.95 Å

PDB Description: crystal structure of human sirt2 in complex with a sirreal probe fragment

PDB Compounds: (A:) nad-dependent protein deacetylase sirtuin-2

SCOPe Domain Sequences for d5dy5a1:

Sequence, based on SEQRES records:

>d5dy5a1 c.31.1.5 (A:56-356) automated matches {Human (Homo sapiens) [TaxId: 9606]}
erlldeltlegvarymqsercrrviclvgagistsagipdfrspstglydnlekyhlpyp
eaifeisyfkkhpepffalakelypgqfkptichyfmrllkdkglllrcytqnidtleri
agleqedlveahgtfytshcvsascrheyplswmkekifsevtpkcedcqslvkpdivff
geslparffscmqsdflkvdlllvmgtslqvqpfasliskaplstprllinkekagqsdp
flgmimglgggmdfdskkayrdvawlgecdqgclalaellgwkkeledlvrrehasidaq
s

Sequence, based on observed residues (ATOM records):

>d5dy5a1 c.31.1.5 (A:56-356) automated matches {Human (Homo sapiens) [TaxId: 9606]}
erlldeltlegvarymqsercrrviclvgagistsagipdfrspstglydnlekyhlpyp
eaifeisyfkkhpepffalakelypgqfkptichyfmrllkdkglllrcytqnidtleri
agleqedlveahgtfytshcvsascrheyplswmkekifsevtpkcedcqslvkpdivff
geslparffscmqsdflkvdlllvmgtslqvqpfasliskaplstprllinkekagqsgm
imglgggmdfdskkayrdvawlgecdqgclalaellgwkkeledlvrrehasidaqs

Timeline for d5dy5a1:

• d5dy5a1 is new in SCOPe 2.06-stable
  
• d5dy5a1 appears in SCOPe 2.07
  
• d5dy5a1 appears in the current release, SCOPe 2.08