SCOPe 2.01: Domain d1fk8b_: 1fk8 B:

Lineage for d1fk8b_ (1fk8 B:)

1. Root: SCOPe 2.01

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein 3-alpha-hydroxysteroid dehydrogenase [51778] (1 species)

7. Species Comamonas testosteroni [TaxId:285] [51779] (2 PDB entries)

8. Domain d1fk8b_: 1fk8 B: [29873]
   complexed with nad

Details for d1fk8b_

PDB Entry: 1fk8, 1.95 Å

PDB Description: the crystal structure of the binary complex with nad of 3-alpha- hydroxysteroid dehydrogenase from comamonas testosteroni, a member of the short chain dehydrogenase/reductase family

PDB Compounds: (B:) 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase

SCOPe Domain Sequences for d1fk8b_:

Sequence, based on SEQRES records:

>d1fk8b_ c.2.1.2 (B:) 3-alpha-hydroxysteroid dehydrogenase {Comamonas testosteroni [TaxId: 285]}
msiivisgcatgigaatrkvleaaghqivgidirdaeviadlstaegrkqaiadvlakcs
kgmdglvlcaglgpqtkvlgnvvsvnyfgatelmdaflpalkkghqpaavvissvasahl
afdknplalaleageeakaraivehageqggnlayagsknaltvavrkraaawgeagvrl
ntiapgatetpllqaglqdprygesiakfvppmgrraepsemasviaflmspaasyvhga
qividggidavmrptqf

Sequence, based on observed residues (ATOM records):

>d1fk8b_ c.2.1.2 (B:) 3-alpha-hydroxysteroid dehydrogenase {Comamonas testosteroni [TaxId: 285]}
msiivisgcatgigaatrkvleaaghqivgidirdaeviadlstaegrkqaiadvlakcs
kgmdglvlcaglgpqtkvlgnvvsvnyfgatelmdaflpalkkghqpaavvissvasahl
afdknplalaleageeakaraivehageqggnlayagsknaltvavrkraaawgeagvrl
ntiapgafvppmgrraepsemasviaflmspaasyvhgaqividggidavmrptqf

Timeline for d1fk8b_:

• d1fk8b_ first appeared (with stable ids) in SCOP 1.55
  
• d1fk8b_ appears in SCOP 1.75
  
• d1fk8b_ appears in SCOPe 2.02
  
• d1fk8b_ appears in the current release, SCOPe 2.08