SCOPe 2.04: Domain d4wwpa4: 4wwp A:726-1090

Lineage for d4wwpa4 (4wwp A:726-1090)

1. Root: SCOPe 2.04

2. Class d: Alpha and beta proteins (a+b) [53931] (380 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.4: Phoshoinositide 3-kinase (PI3K), catalytic domain [56171] (1 protein)

6. Protein Phoshoinositide 3-kinase (PI3K), catalytic domain [56172] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56174] (57 PDB entries)

8. Domain d4wwpa4: 4wwp A:726-1090 [262145]
   Other proteins in same PDB: d4wwpa1, d4wwpa2, d4wwpa3
   automated match to d1e7ua4
   complexed with 3ve, gol, so4

Details for d4wwpa4

PDB Entry: 4wwp, 2.4 Å

PDB Description: crystal structure of human pi3k-gamma in complex with pyridinylquinoline inhibitor n-{(1s)-1-[8-chloro-2-(2-methylpyridin- 3-yl)quinolin-3-yl]ethyl}-9h-purin-6-amine

PDB Compounds: (A:) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d4wwpa4:

Sequence, based on SEQRES records:

>d4wwpa4 d.144.1.4 (A:726-1090) Phoshoinositide 3-kinase (PI3K), catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
tamlhdftqqvqviemlqkvtldikslsaekydvssqvisqlkqklenlqnsqlpesfrv
pydpglkagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlil
qilrimesiwetesldlcllpygcistgdkigmieivkdattiakiqqstvgntgafkde
vlnhwlkekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidf
ghilgnyksflginkervpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtn
lliilfsmmlmtgmpqltskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfn
wflhl

Sequence, based on observed residues (ATOM records):

>d4wwpa4 d.144.1.4 (A:726-1090) Phoshoinositide 3-kinase (PI3K), catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
tamlhdftqqvqviemlqkvtldikslsdvssqvisqlkqklenlqnsqlpesfrvpydp
glkagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqilr
imesiwetesldlcllpygcistgdkigmieivkdattiakiqqstvgntgafkdevlnh
wlkekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidfghik
ervpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtgmp
tskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflhl

Timeline for d4wwpa4:

• d4wwpa4 is new in SCOPe 2.04-stable
  
• d4wwpa4 appears in SCOPe 2.05
  
• d4wwpa4 appears in the current release, SCOPe 2.08