SCOPe 2.04: Domain d4wwpa1: 4wwp A:148-321

Lineage for d4wwpa1 (4wwp A:148-321)

1. Root: SCOPe 2.04

2. Class d: Alpha and beta proteins (a+b) [53931] (380 folds)

3. Fold d.15: beta-Grasp (ubiquitin-like) [54235] (14 superfamilies)
   core: beta(2)-alpha-beta(2); mixed beta-sheet 2143

4. Superfamily d.15.1: Ubiquitin-like [54236] (9 families)

5. Family d.15.1.5: Ras-binding domain, RBD [54263] (14 proteins)
   contains Pfam PF00788 and Pfam PF02196

6. Protein Phoshoinositide 3-kinase (PI3K) [54274] (2 species)
   includes parts of the flanking linkers

7. Species Human (Homo sapiens) [TaxId:9606] [54276] (57 PDB entries)

8. Domain d4wwpa1: 4wwp A:148-321 [262141]
   Other proteins in same PDB: d4wwpa2, d4wwpa3, d4wwpa4
   automated match to d1e7ua3
   complexed with 3ve, gol, so4

Details for d4wwpa1

PDB Entry: 4wwp, 2.4 Å

PDB Description: crystal structure of human pi3k-gamma in complex with pyridinylquinoline inhibitor n-{(1s)-1-[8-chloro-2-(2-methylpyridin- 3-yl)quinolin-3-yl]ethyl}-9h-purin-6-amine

PDB Compounds: (A:) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d4wwpa1:

Sequence, based on SEQRES records:

>d4wwpa1 d.15.1.5 (A:148-321) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
qafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvtskpl
peylwkkianncifivihrsttsqtikvspddtpgailqsfftkmakkkslmdipesqse
qdfvlrvcgrdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrke

Sequence, based on observed residues (ATOM records):

>d4wwpa1 d.15.1.5 (A:148-321) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
qafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvtskpl
peylwkkianncifivihrsttsqtikvspddtpgailqvlrvcgrdeylvgetpiknfq
wvrhclkngeeihvvldtppdpaldevrke

Timeline for d4wwpa1:

• d4wwpa1 is new in SCOPe 2.04-stable
  
• d4wwpa1 appears in SCOPe 2.05
  
• d4wwpa1 appears in the current release, SCOPe 2.08