SCOPe 2.05: Domain d4ezla1: 4ezl A:143-320

Lineage for d4ezla1 (4ezl A:143-320)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.15: beta-Grasp (ubiquitin-like) [54235] (14 superfamilies)
   core: beta(2)-alpha-beta(2); mixed beta-sheet 2143

4. Superfamily d.15.1: Ubiquitin-like [54236] (9 families)

5. Family d.15.1.5: Ras-binding domain, RBD [54263] (14 proteins)
   contains Pfam PF00788 and Pfam PF02196

6. Protein Phoshoinositide 3-kinase (PI3K) [54274] (2 species)
   includes parts of the flanking linkers

7. Species Human (Homo sapiens) [TaxId:9606] [54276] (58 PDB entries)

8. Domain d4ezla1: 4ezl A:143-320 [251841]
   Other proteins in same PDB: d4ezla2, d4ezla3, d4ezla4
   automated match to d1e7ua3
   complexed with 0se

Details for d4ezla1

PDB Entry: 4ezl, 2.94 Å

PDB Description: Potent and Selective Inhibitors of PI3K-delta: Obtaining Isoform Selectivity from the Affinity Pocket and Tryptophan Shelf

PDB Compounds: (A:) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d4ezla1:

Sequence, based on SEQRES records:

>d4ezla1 d.15.1.5 (A:143-320) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
mseesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwv
tskplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmakkkslmdip
esqseqdfvlrvcgrdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrk

Sequence, based on observed residues (ATOM records):

>d4ezla1 d.15.1.5 (A:143-320) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
mseesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwv
tskplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkeqdfvlrvcgr
deylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrk

Timeline for d4ezla1:

• d4ezla1 first appeared in SCOPe 2.04
  
• d4ezla1 appears in SCOPe 2.06
  
• d4ezla1 appears in the current release, SCOPe 2.08